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. 2016 Jul;95(27):e4054.
doi: 10.1097/MD.0000000000004054.

Racial patterns of patients with primary mediastinal large B-cell lymphoma: SEER analysis

Pan-Pan Liu  1 , Ke-Feng Wang, Yi Xia, Xi-Wen Bi, Peng Sun, Yu Wang, Zhi-Ming Li, Wen-Qi Jiang
Affiliations

Racial patterns of patients with primary mediastinal large B-cell lymphoma: SEER analysis

Pan-Pan Liu et al. Medicine (Baltimore). 2016 Jul.

Abstract

The aim of this study is to investigate the incidence and clinical outcomes of primary mediastinal large B-cell lymphoma (PMBL).Here we did a retrospective analysis using the surveillance, epidemiology, and end results (SEER) database to analyze the incidences and survival of patients with PMBL diagnosed during 2001-2012 among major ethnic groups.During 2001-2012, a total of 426 PMBL patients were identified, including 336 whites, 46 blacks, and 44 others. The incidence rates of female to male ratios in white, black, and other were 1.4938, 1.1202, and 1.7303 respectively, suggesting that the female-prominent disease occurrence was seen only in whites and others, but not in black population. Compared to white, the other had a worse 5-year overall survival (OS); however, factors including age, race, socioeconomic status, and stage associated with OS showed no significant difference among ethnic groups; thus, biology factors should be explored to explain the racial difference in OS.In conclusion, our findings revealed diversities in demographic features and prognosis among different racial groups.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Selection of study cohort is shown. This figure provides an overview of the study cohort with reasons for inclusion/exclusion through the selection process. The numbers in boldface denote the cases included in the incidence and survival analyses. ICD-O-3 = International Classification of Diseases for Oncology, third edition; PMBL = primary mediastinal large B-cell lymphoma, SEER = surveillance, epidemiology, and end results.
Figure 2
Figure 2
Trends in incidence of PMBL during the time period covered in this study according to race and sex. All incidence rates are age-adjusted to the 2000 US population and expressed as per 1000,000 population. PMBL = primary mediastinal large B-cell lymphoma.
Figure 3
Figure 3
Age distribution of PMBL is shown by race. (A) Age-specific incidence rates by race, SEER-18, 2001 to 2012. (B) Horizontal axis represents the grouping of age at diagnosis. Vertical axis represents the proportion of patients in each age group of that particular race (white, black, and others). PMBL = primary mediastinal large B-cell lymphoma, SEER = surveillance, epidemiology, and end results.
Figure 4
Figure 4
Kaplan–Meier curves for overall survival in patients with PMBL: (A) years diagnosed 2001 to 2005 vs 2006 to 2012; (B) by age; (C) by race; (D) by stage; (E) by sex; (F) by socioeconomic status. PMBL = primary mediastinal large B-cell lymphoma.
Figure 5
Figure 5
Kaplan–Meier curves for overall survival in patients received with or without radiation therapy: (A) years diagnosed 2001 to 2012; (B) years diagnosed 2001 to 2005; (C) years diagnosed 2006 to 2012.
See this image and copyright information in PMC

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