Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2016 Jul 11;17(1):78.
doi: 10.1186/s12882-016-0293-8.

Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis

Sharanya Ramesh  1 , Ann Zalucky  1 , Brenda R Hemmelgarn  2   3 , Derek J Roberts  3   4 , Sofia B Ahmed  1   5 , Stephen B Wilton  1   5 , Min Jun  6   7   8
Affiliations
Meta-Analysis

Incidence of sudden cardiac death in adults with end-stage renal disease: a systematic review and meta-analysis

Sharanya Ramesh et al. BMC Nephrol. .

Abstract

Background: Although sudden cardiac death (SCD) is recognized as a distinct cause of death in patients with end stage renal disease (ESRD), its incidence has not been well summarized.

Methods: We performed a systematic review and meta-analysis of the literature based on a protocol developed a priori. We searched MEDLINE and EMBASE (inception to March 2015) for randomized controlled trials and cohort studies reporting the incidence of SCD in adult patients with ESRD on hemodialysis or peritoneal dialysis. We collected data on number of SCD as well as the definition of SCD for each individual study. A random-effects model was used to summarize the incidence of SCD. We conducted subgroup analyses to explore sources of heterogeneity.

Results: Forty two studies (n = 80,382 patients) were included in the meta-analysis. The incidence of SCD among adults with ESRD ranged from 0.4 to 10.04 deaths per 100 person-years. The definitions and assessment of SCD varied across the included studies. There was evidence of significant heterogeneity (I(2) = 98; p < 0.001), which was not explained by subgroup analyses stratified by mean age, proportion of hypertensive or diabetic patients, follow-up time, study size, or type of cohort studied.

Conclusion: Current estimates of the incidence of SCD among adults with ESRD vary widely. There is a need for further studies to more accurately estimate the incidence of SCD in patients with ESRD.

Keywords: End stage renal disease; Incidence; Sudden cardiac death; Systematic review.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
PRISMA flow diagram showing the identification process for eligible studies
Fig. 2
Fig. 2
Risk of Bias Assessment
Fig. 3
Fig. 3
Estimated incidence rate
Fig. 4
Fig. 4
Subgroup analysis
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gilbertson DT, Liu J, Xue JL, Louis TA, Solid CA, Ebben JP, Collins AJ. Projecting the number of patients with end-stage renal disease in the United States to the year 2015. J Am Soc Nephrol. 2005;16(12):3736–41. doi: 10.1681/ASN.2005010112. - DOI - PubMed
    1. Ligot AP. CMAJ on the Web. Can Med Assoc J. 2003;168(12):1528–8. - PMC - PubMed
    1. Hallan SI, Coresh J, Astor BC, Åsberg A, Powe NR, Romundstad S, Hallan HA, Lydersen S, Holmen J. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol. 2006;17(8):2275–84. - PubMed
    1. System URD . USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and end-Stage Renal Disease in the United States. Bethesda: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
    1. Shamseddin MK, Parfrey PS. Sudden cardiac death in chronic kidney disease: epidemiology and prevention. Nat Rev Nephrol. 2011;7(3):145–54. doi: 10.1038/nrneph.2010.191. - DOI - PubMed

Grants and funding