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Review
. 2016 Aug;36(3):547-57.
doi: 10.1016/j.iac.2016.03.004.

Biomarkers in Severe Asthma

Xiao Chloe Wan  1 , Prescott G Woodruff  2
Affiliations
Review

Biomarkers in Severe Asthma

Xiao Chloe Wan et al. Immunol Allergy Clin North Am. 2016 Aug.

Abstract

Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non-type 2 inflammatory mechanisms in asthma will soon be the major obstacle to the development of new treatments and management strategies in severe asthma. Biomarkers can play a role in these investigations as well by providing insight into the underlying biology in human studies of patients with severe asthma.

Keywords: Biomarker; Endotype; Eosinophil; Exhaled nitric oxide; Periostin; Severe asthma.

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