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Comparative Study
. 2016 Aug;26(8):521-526.
doi: 10.1016/j.annepidem.2016.06.008. Epub 2016 Jun 17.

Relation of longitudinal changes in body mass index with atherosclerotic cardiovascular disease risk scores in middle-aged black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Duke Appiah  1 , Pamela J Schreiner  2 , Raegan W Durant  3 , Catarina I Kiefe  4 , Catherine Loria  5 , Cora E Lewis  3 , O Dale Williams  6 , Sharina D Person  4 , Stephen Sidney  7
Affiliations
Comparative Study

Relation of longitudinal changes in body mass index with atherosclerotic cardiovascular disease risk scores in middle-aged black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Duke Appiah et al. Ann Epidemiol. 2016 Aug.

Abstract

Purpose: We assessed whether longitudinal changes in body mass index (BMI) are positively associated with changes in 10-year American College of Cardiology/American Heart Association atherosclerotic cardiovascular disease (ASCVD) risk scores in middle-aged blacks compared to whites.

Methods: Data were from 1691 participants enrolled in the Coronary Artery Risk Development in Young Adults Study aged 40 years or more in 2000-2001, who had follow-up examinations 5 and 10 years later.

Results: The prevalence of obesity increased from 32.3% in 2000-2001 (mean age: 42.8 years) to 41.7% in 2010-2011, higher in blacks than whites. The corresponding change in 10-year ASCVD risk was significantly higher for blacks (men: 4.5%-9.6%, women: 1.7%-5.0%) than whites (men: 2.4%-5.2%, women: 0.7%-1.6%). In 2010-2011, 57.5% of black men had ASCVD risk scores of 7.5% or more compared to white men (14.7%), black women (17.4%), and white women (1.6%). Although BMI trends were positively associated with 10-year change in ASCVD risk scores (0.07% per 1 kg/m(2) increase), it explained very little variance in risk score trends in all race-sex groups.

Conclusions: In middle-aged adults, longitudinal changes in BMI had little independent influence on changes in 10-year ASCVD risk scores as its effect may be largely mediated through ASCVD risk factors already accounted for in the risk score.

Keywords: Cardiovascular disease; Obesity; Risk prediction.

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Figures

Figure 1
Figure 1
Proportion of participants with ASCVD risk scores ≥ 7.5% by race, the CARDIA study.
Figure 2
Figure 2
Estimated 10-year ASCVD risk scores among men and women by race, the CARDIA study. Comparison of unadjusted and adjusted risk trends: black men: p = 0.669; white men: p = 0.829; black women p = 0.82; white women: p = 0.830.
See this image and copyright information in PMC

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