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Case Reports
. 2016 May 2;10(1):174-80.
doi: 10.1159/000445867. eCollection 2016 Jan-Apr.

Pancreatic Acinar Cell Carcinoma

Dominique Béchade  1 , Marie Desjardin  1 , Emma Salmon  1 , Grégoire Désolneux  1 , Yves Bécouarn  1 , Serge Evrard  1 , Marianne Fonck  1
Affiliations
Case Reports

Pancreatic Acinar Cell Carcinoma

Dominique Béchade et al. Case Rep Gastroenterol. .

Abstract

Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms. Here we report two cases of ACC and describe their clinical features, the therapies used to treat them, and their prognosis. The first patient was a 65-year-old woman who had an abdominal CT scan for a urinary infection. Fortuitously, a rounded and well-delimited corporeal pancreatic tumor was discovered. An endoscopic ultrasound (EUS)-guided fine needle aspiration revealed an ACC. During the puncture, a hypoechoic cavity appeared inside the lesion, corresponding to a probable necrotic area. Treatment consisted of a distal splenopancreatectomy. The second patient was a 75-year-old man who complained of abdominal pain. An abdominal CT scan showed a cephalic pancreatic lesion and two hepatic metastases. An EUS-guided fine needle aspiration showed a pancreatic ACC. The patient received chemotherapy with gemcitabine plus oxaliplatin (GEMOX regimen), which enabled an objective response after 6 cycles.

Keywords: Acinar cell carcinoma; Pancreas.

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Figures

Fig. 1
Fig. 1
Abdominal CT. Pancreatic tumor mass compared to the celiac region.
Fig. 2
Fig. 2
EUS. Rounded lesion with clear borders (arrow).
Fig. 3
Fig. 3
Appearance of a hypoechoic cavity within the lesion during puncture using EUS (arrow).
Fig. 4
Fig. 4
A Positive staining with BCL10. ×200. B Negative staining with CK7. There is a cytoplasmic background without membrane staining. ×100.
Fig. 5
Fig. 5
Abdominal CT. Bulky tumor mass in the pancreatic head measuring 80.3 mm (long axis).
Fig. 6
Fig. 6
Therapeutic response obtained after 6 cycles of GEMOX treatment.
See this image and copyright information in PMC

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