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Comment
. 2016 Jul 11;26(13):R539-R542.
doi: 10.1016/j.cub.2016.05.032.

Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation

Jason M Berk  1 , Mark Hochstrasser  2
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Protein Modification: Bacterial Effectors Rewrite the Rules of Ubiquitylation

Jason M Berk et al. Curr Biol. .
Free article

Abstract

A family of virulence factors from the bacterial pathogen Legionella pneumophila has been discovered to modify human Rab GTPases with ubiquitin. Surprisingly, this modification occurs via a non-canonical mechanism that uses nicotinamide adenine dinucleotide as a cofactor.

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