Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Apr;57(2):126-8.
doi: 10.1016/S0377-1237(01)80130-1. Epub 2011 Jul 21.

PRENATAL DIAGNOSIS OF NEURAL TUBE DEFECTS

S G Gupta  1 , H Singh  2
Affiliations

PRENATAL DIAGNOSIS OF NEURAL TUBE DEFECTS

S G Gupta et al. Med J Armed Forces India. 2001 Apr.

Abstract

14 cases of neural tube defect (NTD) were detected on screening of 1950 pregnant women over a period of 30 months by antenatal ultrasonography (USG) examination, suggesting an incidence of 7.1 per thousand conceptions. The distribution of types of NTD were occult dysraphism 14%, meningocele 14%, myelocele 7%, myelomeningocele 14%, encephalocele 14% and anencephaly 37%. The study established high accuracy of USG screening for antenatal diagnosis of NTD with sensitivity of 85.71% and specificity of 100.

Keywords: Neural tube defect.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Fetal cranial scan showing bilobed cystic brain structure protruding out from occiput
Fig. 2
Fig. 2
Fetal head scan showing “Lemon sign” as a result of small posterior fossa and cerebellum.
Fig. 3
Fig. 3
Fetal head scan showing orbits but absent cranial vault.
See this image and copyright information in PMC

References

    1. Michael JN. Myelomeningocele: Current concpts of management. Clinics in Perinatology. 1989;16:311–312. - PubMed
    1. Sood M, Agarwal N, Verma S, Bhargava SK. Neural tube defects in an east Delhi hospital. Ind J Pediatrics. 1991;58:363–365. - PubMed
    1. Volpe JJ. Neurology of Newborns. 3rd ed. WB Saunders; USA: 1995. pp. 14–15.
    1. Filly RA. Ultrasound evaluation of the foetal neural axis. In: Callen PW, editor. Ultrasonography in obstetrics and gynaecology. 2nd ed. WB Saunders; Philadelphia: 1988. pp. 123–131.
    1. Winsor EJ, Brown BS. Prevalence and prenatal diagnosis of neural tube defects in Nova Scotia in 1980–84. Can Med Assoc J. 1986;135:1269–1273. - PMC - PubMed

LinkOut - more resources