Misoprostol as aid in First Trimester MTP
- PMID: 27407834
- PMCID: PMC4923270
- DOI: 10.1016/S0377-1237(06)80144-9
Misoprostol as aid in First Trimester MTP
Abstract
Background: Medical Termination of Pregnancy (MTP) is a commonly performed during the first trimester. Dilatation and Evacuation (D & E) mandates rapid dilatation of cervix with metal dilators, which requires anaesthesia and may be associated with trauma to the uterus, cervix and later cervical incompetence. The problem of rapid cervical dilatation is obviated with intravaginal misoprostol.
Methods: Intravaginal misoprostol tablet 200 microgram was inserted, a night prior to MTP to ripen the cervix. Cervix was dilated with metal dilators only in cases where cervix did not loosen up sufficiently. Products of conception were removed by suction.
Results: Out of 108 cases cervical dilatation was not required in 96 cases (88.9%).
Conclusion: Intravaginal misoprostol 200 microgram proved effective as a priming agent prior to MTP in the first trimester.
Keywords: MTP; Misoprostol.
Similar articles
-
Sublingual misoprostol before first trimester abortion: a comparative study using two dose regimens.Indian J Med Sci. 2004 Feb;58(2):54-61. Indian J Med Sci. 2004. PMID: 14993717 Clinical Trial.
-
Sublingual misoprostol for cervical priming in surgical first trimester pregnancy termination.J Obstet Gynaecol India. 2011 Oct;61(5):531-3. doi: 10.1007/s13224-011-0082-z. Epub 2011 Oct 29. J Obstet Gynaecol India. 2011. PMID: 23024523 Free PMC article.
-
A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation.Obstet Gynecol. 2003 Sep;102(3):583-8. doi: 10.1016/s0029-7844(03)00514-3. Obstet Gynecol. 2003. PMID: 12962946 Clinical Trial.
-
[Misoprostol: off-label use in the first trimester of pregnancy (spontaneous abortion, and voluntary medical termination of pregnancy)].J Gynecol Obstet Biol Reprod (Paris). 2014 Feb;43(2):123-45. doi: 10.1016/j.jgyn.2013.11.007. Epub 2014 Jan 13. J Gynecol Obstet Biol Reprod (Paris). 2014. PMID: 24433988 Review. French.
-
Overview and expert assessment of off-label use of misoprostol in obstetrics and gynaecology: review and report by the Collège national des gynécologues obstétriciens français.Eur J Obstet Gynecol Reprod Biol. 2015 Apr;187:80-4. doi: 10.1016/j.ejogrb.2015.01.018. Epub 2015 Jan 31. Eur J Obstet Gynecol Reprod Biol. 2015. PMID: 25701235 Review.
References
-
- Koering MJ, Healy DI, Coddington CC. Morphological response of endometrium to progesterone antagonists in monkeys. Ferti Steril. 1986;45:280–287. - PubMed
-
- Spitz IM, Bardin CW. RU-486 — A modulator of progestin and glucocorticoid action. N Engl J Med. 1993;329:404–412. - PubMed
-
- Norman JE, Thong KJ, Baird DT. Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifeprostone. Lancet. 1991;338:11233–11236. - PubMed
-
- Peyron R, Aubeny E, Targosz V. Early termination of pregnancy with mifepristone (RU 486) and the orally active prostaglandin misoprostol. N Engl J Med. 1993;328:1509–1513. - PubMed
-
- Spitz IM, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med. 1998;338:1241–1247. - PubMed
LinkOut - more resources
Full Text Sources