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Review
. 2016 Jun 16:6:1-7.
doi: 10.1016/j.lrr.2016.06.001. eCollection 2016.

Acute myeloid leukemia in the older adults

Antonio M Almeida  1 , Fernando Ramos  2
Affiliations
Review

Acute myeloid leukemia in the older adults

Antonio M Almeida et al. Leuk Res Rep. .

Abstract

AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult therapeutic challenge. In this context, it is important to assess carefully patient- as well as disease-associated prognostic features with validated tools. The fittest patients should be considered for curative therapy, such as bone marrow transplantation, whereas low intensity options may be more appropriate for frail patients. Here we review how to assess patients with elderly AML and the treatments options available for them.

Keywords: Acute myeloid leukemia; Elderly; Geriatric assessment; Prognosis; Therapy.

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Figures

Fig. 1
Fig. 1
Overall survival by European ALMA Score. Full patient series. The tick marks on the curves represent censored patients.
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