Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun 16:6:1-7.
doi: 10.1016/j.lrr.2016.06.001. eCollection 2016.

Acute myeloid leukemia in the older adults

Antonio M Almeida  1 , Fernando Ramos  2
Affiliations
Review

Acute myeloid leukemia in the older adults

Antonio M Almeida et al. Leuk Res Rep. .

Abstract

AML is an aggressive hematological malignancy with highest incidence in the older adults. The adverse features of AML in the elderly, and the frailties and comorbidities frequently present in them, make their management a particularly difficult therapeutic challenge. In this context, it is important to assess carefully patient- as well as disease-associated prognostic features with validated tools. The fittest patients should be considered for curative therapy, such as bone marrow transplantation, whereas low intensity options may be more appropriate for frail patients. Here we review how to assess patients with elderly AML and the treatments options available for them.

Keywords: Acute myeloid leukemia; Elderly; Geriatric assessment; Prognosis; Therapy.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Overall survival by European ALMA Score. Full patient series. The tick marks on the curves represent censored patients.
See this image and copyright information in PMC

References

    1. Cancer Statistics Review 1975–2003: I Table–11median age of cancer patients at diagnosis, 2000–2003 by primary cancersite, race and sex. [database on the Internet]. National Cancer Institute. (cited 01.02.16), 2003.
    1. Alibhai S.M., Leach M., Minden M.D., Brandwein J. Outcomes and quality of care in acute myeloid leukemia over 40 years. Cancer. 2009;115(13):2903–2911. - PubMed
    1. Menzin J., Lang K., Earle C.C., Kerney D., Mallick R. The outcomes and costs of acute myeloid leukemia among the elderly. Arch. Intern Med. 2002;162(14):1597–1603. - PubMed
    1. Global Health Observatory Data (database on the Internet). WHO. (cited 01.02.16), 2016. Available from: 〈http://www.who.int/gho/mortality_burden_disease/life_tables/life_tables....
    1. Mohammadi M., Cao Y., Glimelius I., Bottai M., Eloranta S., Smedby K.E. The impact of comorbid disease history on all-cause and cancer-specific mortality in myeloid leukemia and myeloma – a Swedish population-based study. BMC Cancer. 2015;15:850. - PMC - PubMed

LinkOut - more resources