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Comment
. 2016 Jul 11;30(1):13-15.
doi: 10.1016/j.ccell.2016.06.019.

Hunger Pains: Stimulating the Appetite of the Immune System for Cancer

Judson M Englert  1 , Jonathan D Powell  2
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Free article
Comment

Hunger Pains: Stimulating the Appetite of the Immune System for Cancer

Judson M Englert et al. Cancer Cell. .
Free article

Abstract

In this issue, Pietrocola et al. and Di Biase et al. independently demonstrate that caloric restriction from fasting and pharmacologic inhibition results in an enhanced immunogenic response leading to reduced tumor growth. These two studies provide an exciting connection between the emerging fields of cancer and immune metabolism.

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  • Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.
    Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Di Biase S, et al. Cancer Cell. 2016 Jul 11;30(1):136-146. doi: 10.1016/j.ccell.2016.06.005. Cancer Cell. 2016. PMID: 27411588 Free PMC article.
  • Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
    Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G. Pietrocola F, et al. Cancer Cell. 2016 Jul 11;30(1):147-160. doi: 10.1016/j.ccell.2016.05.016. Cancer Cell. 2016. PMID: 27411589 Free PMC article.

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