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. 2016 Sep;39(9):1550-5.
doi: 10.2337/dc16-0429. Epub 2016 Jul 13.

Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study

Qiuhong Gong  1 , Ping Zhang  2 , Jinping Wang  3 , Yali An  1 , Edward W Gregg  4 , Hui Li  3 , Bo Zhang  5 , Ying Shuai  5 , Wenying Yang  5 , Yanyan Chen  1 , Shuqian Liu  6 , Michael M Engelgau  7 , Yinghua Hu  3 , Peter H Bennett  8 , Guangwei Li  9
Affiliations

Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study

Qiuhong Gong et al. Diabetes Care. 2016 Sep.

Abstract

Objective: People with impaired glucose tolerance (IGT) have increased risk of mortality and a high risk of progression to diabetes, but the extent that the excess mortality is associated with IGT per se or is the result of subsequent diabetes is unclear.

Research design and methods: We compared mortality before and after the development of diabetes among 542 persons with IGT initially who participated in a 6-year lifestyle diabetes prevention trial and were followed-up from 1986 to 2009.

Results: During the 23-year follow-up, 174 (32.1%) died, with an overall death rate of 15.9/1,000 person-years. The majority of deaths (74.7%; 130 of 174) occurred after progression to type 2 diabetes, with age-adjusted death rates of 11.1/1,000 person-years (95% CI 8.2-12.0) before and 19.4/1,000 person-years (95% CI 11.9-23.3) after the development of type 2 diabetes. The cumulative mortality was 37.8% (95% CI 33.1-42.2%) in participants who developed type 2 diabetes during first 10 years of follow-up, 28.6% (95% CI 21.6-35.0%) in those who progressed to type 2 diabetes in 10-20 years, and 13.9% (95% CI 7.0-20.3%) in those who did not develop to type 2 diabetes within 20 years. Time-dependent multivariate Cox proportional hazards analyses, with adjustment for baseline age, sex, intervention, and other potential confounding risk factors, showed that the development of type 2 diabetes was associated with a 73% higher risk of death (hazard ratio 1.73 [95% CI 1.18-2.52]).

Conclusions: As elsewhere, IGT is associated with increased risk of mortality in China, but much of this excess risk is attributable to the development of type 2 diabetes.

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Figures

Figure 1
Figure 1
Age-, sex-, and intervention-adjusted cumulative incidence of death according to time to development of diabetes. The white circles represent those who developed diabetes during the first 10 years of follow-up; the black circles, those who developed diabetes between 10 and 20 years of follow-up; and the white squares, those who never developed diabetes or developed diabetes after 20 or more years of follow-up.
See this image and copyright information in PMC

References

    1. Yang W, Lu J, Weng J, et al. .; China National Diabetes and Metabolic Disorders Study Group . Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090–1101 - PubMed
    1. Xu Y, Wang L, He J, et al. .; 2010 China Noncommunicable Disease Surveillance Group . Prevalence and control of diabetes in Chinese adults. JAMA 2013;310:948–959 - PubMed
    1. An Y, Zhang P, Wang J, et al. . Cardiovascular and all-cause mortality over a 23-year period among Chinese with newly diagnosed diabetes in the Da Qing IGT and Diabetes Study. Diabetes Care 2015;38:1365–1371 - PMC - PubMed
    1. Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 2006;332:73–78 - PMC - PubMed
    1. Ma S, Cutter J, Tan CE, Chew SK, Tai ES. Associations of diabetes mellitus and ethnicity with mortality in a multiethnic Asian population: data from the 1992 Singapore National Health Survey. Am J Epidemiol 2003;158:543–552 - PubMed