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. 2016 Aug;4(3):206-9.
doi: 10.1093/gastro/gow017. Epub 2016 Jul 12.

Neoadjuvant treatment of rectal cancer: where are we now?

Aparna Kalyan  1 , Shaina Rozelle  2 , Al Benson 3rd  2
Affiliations

Neoadjuvant treatment of rectal cancer: where are we now?

Aparna Kalyan et al. Gastroenterol Rep (Oxf). 2016 Aug.
No abstract available

Keywords: 5-fluorouracil; local recurrence; neoadjuvant chemoradiation; rectal cancer.

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Figures

Figure 1.
Figure 1.
Schema for PROSPECT study. FOLFOX: 5FU/leucovorin + Oxaliplatin; CRT: chemoradiation therapy; LAR: low anterior resection; TME: total mesorectal excision; Cap: Capecitabine The PROSPECT study is evaluating preoperative RT followed by surgery and adjuvant therapy (the current standard of care) versus selective preoperative RT and evaluation before TME. The study aims to reduce the use of pelvic RT in patients who might not benefit from this treatment. All patients who meet criteria will be randomized in a 1:1 fashion.
Figure 2.
Figure 2.
Schema for FORWARC study (adapted from Jianping Wang) Arm A: Traditional CRT followed by surgical resection. Patients then received adjuvant chemotherapy. Chemotherapy was given per the De Gramont regimen consisting of bolus 5FU/LV as well as infusional 5FU. Arm B: Neoadjuvant mFOLFOX with combined RT therapy followed by surgical resection. Adjuvant chemotherapy consisted of mFOLFOX. Arm C: Neoadjuvant chemotherapy with mFOLFOX followed by surgery and adjuvant therapy.
See this image and copyright information in PMC

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