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Comparative Study
. 1989 Jan-Feb;61(1):75-8.

[Activity of key enzymes of heme metabolism and the content of several hemoproteins in the liver of rats of various ages]

[Article in Russian]
P A Kaliman, I V Nikitchenko
  • PMID: 2741245
Comparative Study

[Activity of key enzymes of heme metabolism and the content of several hemoproteins in the liver of rats of various ages]

[Article in Russian]
P A Kaliman et al. Ukr Biokhim Zh (1978). 1989 Jan-Feb.

Abstract

The activity of key enzymes of heme metabolism (delta-aminolevulinate synthase, EC 2.3.1.37, and heme oxygenase, EC 1.14.99.3) and the content of some hemoproteins were examined in the liver of male Wistar rats aged 1, 3 and 24 months. It is established that the activity of delta-aminolevulinate synthase decreases when rats reach the age of 3 months and remains at the same level in rats aged 24 months. The content of microsomal cytochrome P450 and the activity of tryptophan-2,3-dioxygenase holoenzyme increase when rats reach the age of 3 months. The total tryptophan-2,3 dioxygenase activity is higher in animals aged 24 months as compared to those aged 1 month. The heme oxygenase activity and the content of microsomal cytochrome b5 do not change with age.

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