Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2016 Jul;18(7):582-8.
doi: 10.7499/j.issn.1008-8830.2016.07.003.

[Lamotrigine monotherapy in children with epilepsy: a systematic review]

[Article in Chinese]
Yan-Tao Liu  1 , Ling-Li Zhang, Liang Huang, Li-Nan Zeng
Affiliations
Meta-Analysis

[Lamotrigine monotherapy in children with epilepsy: a systematic review]

[Article in Chinese]
Yan-Tao Liu et al. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Jul.

Abstract
in English, Chinese

Objective: To investigate the efficacy and safety of lamotrigine monotherapy in children with epilepsy via a systematic review.

Methods: PubMed, Cochrane, CNKI, VIP, CBM, Wanfang Data were searched for randomized controlled trials (RCTs) of lamotrigine monotherapy in children with epilepsy. Literature screening, data extraction, and quality assessment were performed according to the method recommended by Cochrane Collaboration. RevMan 5.2 software was used to conduct the Meta analysis.

Results: A total of 9 RCTs involving 1 016 participants were included. Lamotrigine yielded a significantly lower complete control rate of seizure than ethosuximide, but the complete control rate of seizure showed no significant differences between lamotrigine and carbamazepine/sodium valproate. Patients treated with lamotrigine had a significantly lower incidence rate of adverse events than those treated with carbamazepine, but the incidence rate of adverse events showed no significant differences between patients treated with lamotrigine and sodium valproate/carbamazepine. The drop-out rate showed no significant differences between the three treatment groups.

Conclusions: Lamotrigine is an ideal alternative drug for children who do not respond to traditional antiepileptic medication or experience significant adverse reactions; however, more high-quality RCTs with a large sample size and a long follow-up time are needed to confirm these conclusions.

目的: 系统评价拉莫三嗪单药治疗儿童癫癎的有效性和安全性。

方法: 计算机检索PubMed、Cochrane图书馆、CNKI、VIP、CBM、万方等中英文数据库，获得拉莫三嗪单药治疗儿童癫癎的随机对照试验。应用Cochrane协作网推荐的方法进行文献筛选，资料提取和文献质量评估，采用RevMan 5.2软件进行Meta分析。

结果: 共纳入9个RCTs（1016例）。拉莫三嗪的癫癎发作完全控制率明显低于乙琥胺，与卡马西平和丙戊酸钠的差异均无统计学意义。拉莫三嗪的不良反应发生率明显低于卡马西平，与丙戊酸钠和乙琥胺的差异均无统计学意义；3种药物的退出率比较差异无统计学意义。

结论: 对于传统抗癫癎药物治疗无效、不良反应明显患儿，拉莫三嗪是一种较为理想的替代药物。但仍有待高质量、大样本及较长随访时间的随机对照试验予以证实。

PubMed Disclaimer

Figures

1
1
拉莫三嗪组和对照组癫癎发作完全控制率比较的Meta分析
2
2
拉莫三嗪组和对照组不良反应发生率比较的Meta分析
3
3
基于癫癎发作完全控制率的漏斗图
4
4
基于治疗期间退出率的漏斗图
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • KBG syndrome involving a single-nucleotide duplication in ANKRD11.
    Kleyner R, Malcolmson J, Tegay D, Ward K, Maughan A, Maughan G, Nelson L, Wang K, Robison R, Lyon GJ. Kleyner R, et al. Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001131. doi: 10.1101/mcs.a001131. Cold Spring Harb Mol Case Stud. 2016. PMID: 27900361 Free PMC article.

References

    1. 吴江.神经病学[M]//北京: 人民卫生出版社. 2005: 264-281.

    1. World Health Organization. Epilepsy. Fact sheet N°999, World Health Organization[EB/OL]. (October, 2012). http://www.who.int/mediacentre/factsheets/fs999/en/index.html.

    1. World Health Organization. Epilepsy Management at Primary Health Level in rural China[EB/OL]. (March, 2009). http://www.who.int/mental_health/neurology/epilepsy_china_report_english.pdf.

    1. 李 雪华. 癫癎的治疗方法研究进展. 临床合理用药. 2012;5(6):155.
    1. 李 世绰, 吴 立文. 中华医学会.临床诊疗指南——癫癎病分册. 北京: 人民卫生出版社; 2007. pp. 48–50.