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. 2016:2016:1794894.
doi: 10.1155/2016/1794894. Epub 2016 Jun 20.

Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Jie Zhang  1 , Jianhong Ye  2 , Gang Guo  2 , Zhenhao Lan  3 , Xing Li  4 , Zhiming Pan  2 , Xianming Rao  2 , Zongji Zheng  5 , Fangtao Luo  2 , Luping Lin  2 , Zhihua Lin  2 , Yaoming Xue  5
Affiliations

Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Jie Zhang et al. Int J Endocrinol. 2016.

Abstract

Objectives. Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus. Little information is available about the association between vitamin D status and insulin resistance in the Chinese population. Currently, vitamin D status is evaluated by the concentrations of serum 25-hydroxyvitamin D [25(OH)D]. This study explores the relationship between insulin resistance and serum 25-hydroxyvitamin D concentrations in Chinese patients with type 2 diabetes mellitus. Subjects and Methods. This study included 117 patients with type 2 diabetes. The following variables were measured: 25-hydroxyvitamin D [25(OH)D], glycosylated hemoglobin A1c (HbA1c), fasting blood glucose (FBS), fasting blood insulin (FINS), fasting blood C-peptide, serum creatinine (SCr), glomerular filtration rate (eGFR), body mass index (BMI), and homeostatic model estimates of insulin resistance (HOMA-IR). Results. The cases were divided into three groups: Group 1 (G1) with 25(OH)D ≤ 20 ng/mL [≤50 nmol/L], Group 2 (G2) with 25(OH)D values from 20 ng/mL [50 nmol/L] to 30 ng/mL [75 nmol/L], and Group 3 (G3) with 25(OH)D ≥ 30 ng/mL [≥75 nmol/L], with 52.6%, 26.3%, and 21.1% of subjects in Groups 1-3, respectively. There was a negative correlation between 25(OH)D and HOMA-IR (β = -0.314, p = 0.001) adjusted by age, BMI, and eGFR. Conclusion. Better vitamin D status may be protective of glucose homeostasis since 25(OH)D was negatively associated with insulin resistance in Chinese patients with type 2 diabetes.

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Figures

Figure 1
Figure 1
Inverse association between 25(OH)D and HOMA-IR (Pearson correlation = −0.327, p = 0.000).
See this image and copyright information in PMC

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