Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province

Tianbo Jin¹, Ruimin Zhao², Xugang Shi¹, Na He³, Xue He³, Yongri Ouyang⁴, Hong Wang⁴, Bo Wang⁴, Longli Kang³, Dongya Yuan⁵

Affiliations

¹ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
² Otorhinolaryngological, Head and Neck Surgery Department, School of Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
³ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
⁴ National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
⁵ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China. Electronic address: dongyayuan163@163.com.

PMID: 27414743
DOI: 10.1016/j.etap.2016.06.026

Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province

Tianbo Jin et al. Environ Toxicol Pharmacol. 2016 Sep.

. 2016 Sep:46:27-35.

doi: 10.1016/j.etap.2016.06.026. Epub 2016 Jun 27.

Authors

Tianbo Jin¹, Ruimin Zhao², Xugang Shi¹, Na He³, Xue He³, Yongri Ouyang⁴, Hong Wang⁴, Bo Wang⁴, Longli Kang³, Dongya Yuan⁵

Affiliations

¹ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
² Otorhinolaryngological, Head and Neck Surgery Department, School of Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
³ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
⁴ National Engineering Research Center for Miniaturized Detection Systems, School of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, China.
⁵ Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China. Electronic address: dongyayuan163@163.com.

PMID: 27414743
DOI: 10.1016/j.etap.2016.06.026

Abstract

Background: Multiple factors include genetic and non-genetic interactions induce to different drug response among different individuals. Lots of researches proved that different frequencies of genetic variants exists different ethnic groups. The aim of this study was to screen Han volunteers in Shaanxi for VIP gene polymorphisms.

Materials and methods: We genotyped 80 Very Important Pharmacogenes (VIP) (selected from the PharmGKB database) in 192 unrelated, healthy Han ethnic adults from Shaanxi, the northwest of China, and then analyzed genotyping data wtih Structure and F-statistics (Fst) analysis.

Results: We compared our data with 15 other populations (Deng, Kyrgyz, Tajik, Uygur and 11 HapMap populations), and found the frequency distribution of Han population in Shaanxi is most similar with CHB. Also, Structure and Fst showed that Shaanxi Han has a closest genetic background with CHB.

Conclusions: Our study have supplemented the Han Chinese data related to pharmacogenomics and illustrated differences in genotypic frequencies of selected VIP variants' among the Han population and 15 other populations.

Keywords: Genetic polymorphisms; Han ethnic; Pharmacogenomics; VIP; Variant.

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Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province

Affiliations

Genetic polymorphisms study of pharmacogenomic VIP variants in Han ethnic of China's Shaanxi province

Authors

Affiliations

Abstract

MeSH terms

LinkOut - more resources

Full Text Sources