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Meta-Analysis
. 2016 Jul 15:6:29943.
doi: 10.1038/srep29943.

Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: a comparative study with aero-digestive lesions

Xiaobo Luo  1 , Hao Xu  1 , Mingjing He  1 , Qi Han  1 , Hui Wang  2 , Chongkui Sun  1 , Jing Li  1 , Lu Jiang  1 , Yu Zhou  1 , Hongxia Dan  1 , Xiaodong Feng  1 , Xin Zeng  1 , Qianming Chen  1
Affiliations
Meta-Analysis

Accuracy of autofluorescence in diagnosing oral squamous cell carcinoma and oral potentially malignant disorders: a comparative study with aero-digestive lesions

Xiaobo Luo et al. Sci Rep. .

Abstract

Presently, various studies had investigated the accuracy of autofluorescence in diagnosing oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) with diverse conclusions. This study aimed to assess its accuracy for OSCC and OPMD and to investigate its applicability in general dental practice. After a comprehensive literature search, a meta-analysis was conducted to calculate the pooled diagnostic indexes of autofluorescence for premalignant lesions (PML) and malignant lesions (ML) of the oral cavity, lung, esophagus, stomach and colorectum and to compute indexes regarding the detection of OSCC aided by algorithms. Besides, a u test was performed. Twenty-four studies detecting OSCC and OPMD in 2761 lesions were included. This demonstrated that the overall accuracy of autofluorescence for OSCC and OPMD was superior to PML and ML of the lung, esophagus and stomach, slightly inferior to the colorectum. Additionally, the sensitivity and specificity for OSCC and OPMD were 0.89 and 0.8, respectively. Furthermore, the specificity could be remarkably improved by additional algorithms. With relatively high accuracy, autofluorescence could be potentially applied as an adjunct for early diagnosis of OSCC and OPMD. Moreover, approaches such as algorithms could enhance its specificity to ensure its efficacy in primary care.

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Figures

Figure 1
Figure 1. Flow diagram shows the selection process of eligible articles that applying autofluorescence to diagnose OSCC and OPMD.
OSCC: oral squamous cell carcinoma; OPMD: oral potentially malignant disorders.
Figure 2
Figure 2. Forest plots of sensitivity and specificity of studies that employing autofluorescence in the diagnosis of OSCC and OPMD.
The solid circles indicate estimates of sensitivity and specificity for each study, and the size of each solid circle represents the sample size of each study. The error bars are 95% confidence intervals. OSCC: oral squamous cell carcinoma; OPMD: oral potentially malignant disorders.
Figure 3
Figure 3. Hierarchical summary receiver operating characteristic curve (HSROC) of studies utilising autofluorescence for the detection of OSCC and OPMD.
Each empty circle represents one study, and the size of every circle indicates the sample size of each study. OSCC: oral squamous cell carcinoma; OPMD: oral potentially malignant disorders.
Figure 4
Figure 4. Begg’s funnel plot for the evaluation of potential publication bias of studies that applying autofluorescence to diagnose OSCC and OPMD.
Each solid circle indicates one study; OSCC: oral squamous cell carcinoma; OPMD: oral potentially malignant disorders.
See this image and copyright information in PMC

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