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Review
. 2014 Sep 12;1(2):227-40.
doi: 10.3390/children1020227.

Clinical Guidelines for the Care of Childhood Cancer Survivors

Emily S Tonorezos  1 , Tara O Henderson  2
Affiliations
Review

Clinical Guidelines for the Care of Childhood Cancer Survivors

Emily S Tonorezos et al. Children (Basel). .

Abstract

The Long-Term Follow-Up Guidelines for survivors of childhood, adolescent, and young adult cancers are evidence- and consensus-based guidelines that have been developed and published by the Children's Oncology Group (COG) Late Effects Committee, Nursing Discipline, and the Patient Advocacy Committee. Originally published in 2004, the guidelines are currently in version 3.0. While the COG guidelines have been praised as a model for providing risk-based survivorship care, adherence has not been uniform. Reasons for this gap include unawareness on the part of the survivor and/or care team as well as disagreement about the individual recommendations. In some cases, the burden of testing (such as annual echocardiography or repeat pulmonary function testing) may be too great. A small number of intervention studies have documented improved adherence to guideline recommendations with dissemination of informational material. Future studies should focus on individualizing screening recommendations, as well as identifying unnecessary testing.

Keywords: childhood cancer; guidelines; survivorship.

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Figures

Figure 1
Figure 1
Five-year relative survival is illustrated for children and adolescents who were ages birth to 4 years, 5 to 14 years, and 15 to 19 years at the time of cancer diagnosis. Data is from the Surveillance, Epidemiology, and End Results (SEER) registries with follow-up through 2010. Reprinted with permission from Smith M.A., et al. [2].
Figure 2
Figure 2
Range of health-related and quality-of-life outcomes among long-term survivors of childhood and adolescent cancers. This figure shows some of the issues that are faced by survivors of childhood and adolescent cancers. GI, gastrointestinal. Reprinted with permission from Robison L.L. and Hudson M.M. [14].
Figure 3
Figure 3
Theoretical model of potential barriers and enablers to the longitudinal cancer-related health care of adult survivors of childhood cancer. Reprinted with permission from Oeffinger, K.C. [33].
See this image and copyright information in PMC

References

    1. Howlader N., Noone A., Krapcho M. Seer Cancer Statistics Review, 1975–2010. National Cancer Institute; Bethesda, MD, USA: 2013.
    1. Smith M.A., Altekruse S.F., Adamson P.C., Reaman G.H., Seibel N.L. Declining childhood and adolescent cancer mortality. Cancer. 2014;120:2497–2506. - PMC - PubMed
    1. Hudson M.M., Neglia J.P., Woods W.G., Sandlund J.T., Pui C.H., Kun L.E., Robison L.L., Green D.M. Lessons from the past: Opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies. Pediatr. Blood Cancer. 2012;58:334–343. doi: 10.1002/pbc.23385. - DOI - PMC - PubMed
    1. Kersey J.H. Fifty years of studies of the biology and therapy of childhood leukemia. Blood. 1997;90:4243–4251. - PubMed
    1. Oeffinger K.C., Mertens A.C., Sklar C.A., Kawashima T., Hudson M.M., Meadows A.T., Friedman D.L., Marina N., Hobbie W., Kadan-Lottick N.S., et al. Chronic health conditions in adult survivors of childhood cancer. N. Engl. J. Med. 2006;355:1572–1582. doi: 10.1056/NEJMsa060185. - DOI - PubMed

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