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Review
. 2016 Jul 15;9(1):55.
doi: 10.1186/s13045-016-0284-z.

Elotuzumab for the treatment of multiple myeloma

Yucai Wang  1 , Larysa Sanchez  1 , David S Siegel  2 , Michael L Wang  3
Affiliations
Review

Elotuzumab for the treatment of multiple myeloma

Yucai Wang et al. J Hematol Oncol. .

Abstract

Elotuzumab is one of the first two monoclonal antibodies that gained FDA approval for the treatment of multiple myeloma (MM). It targets SLAMF7, which is highly expressed in normal plasma and MM cells as well as natural killer (NK) cells. Elotuzumab demonstrated significant anti-myeloma activity in preclinical studies, and its mechanisms of action include mediating antibody-dependent cell-mediated cytotoxicity, enhancing cytotoxicity of NK cells, and inhibiting MM cell interaction with bone marrow stromal cells. In clinical trials, elotuzumab in combination with immunomodulatory drugs and proteasome inhibitors has demonstrated an excellent efficacy and safety profile in treating MM.

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Figures

Fig. 1
Fig. 1
The mechanisms of action of elotuzumab. Upper left, elotuzumab binds SLAMF7 on MM cells, and its Fc fragment is then bound by CD16 on NK cells, mediating ADCC. Upper right, elotuzumab binds SLAMF7 on NK cells, directly enhancing its cytotoxicity. Bottom right, elotuzumab binds SLAMF7 on MM cells, inhibiting its interaction with BMSCs. NK cell natural killer cell; MM cell multiple myeloma cell; BMSC bone marrow stromal cell; ADCC antibody-dependent cellular cytotoxicity
See this image and copyright information in PMC

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