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. 2016 May;468(1):168-72.
doi: 10.1134/S1607672916030029. Epub 2016 Jul 15.

(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

P E Menschikov  1 , N A Semenova  2   3   4 , M V Ublinskiy  2   3 , T A Akhadov  3 , R A Keshishyan  3 , I S Lebedeva  5 , M A Omelchenko  5 , V G Kaleda  5 , S D Varfolomeev  2
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(1)H-MRS and MEGA-PRESS pulse sequence in the study of balance of inhibitory and excitatory neurotransmitters in the human brain of ultra-high risk of schizophrenia patients

P E Menschikov et al. Dokl Biochem Biophys. 2016 May.

Abstract

The MEGA-PRESS pulse sequence was used for determination of overlapping signals in the (1)H-MRS spectra of the human brain. For the first time, the balance of GABA glutamate/glutamine concentrations was estimated quantitatively in the human brain of patients with ultra-high risk of schizophrenia. It was found that GABA concentration and GABA/GLX ratios were significantly reduced in the left frontal lobe of UHR subjects.

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