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Case Reports
. 2016 Nov 1;63(9):1198-1201.
doi: 10.1093/cid/ciw476. Epub 2016 Jul 14.

Zika Virus Infection Associated With Severe Thrombocytopenia

Tyler M Sharp  1 , Jorge Muñoz-Jordán  1 , Janice Perez-Padilla  1 , Melissa I Bello-Pagán  2 , Aidsa Rivera  1 , Daniel M Pastula  3 , Jorge L Salinas  4 , Jose H Martínez Mendez  5 , Mónica Méndez  6 , Ann M Powers  7 , Stephen Waterman  1 , Brenda Rivera-García  2
Affiliations
Case Reports

Zika Virus Infection Associated With Severe Thrombocytopenia

Tyler M Sharp et al. Clin Infect Dis. .

Abstract

We report two patients that developed severe thrombocytopenia after Zika virus (ZIKV) infection. The first patient had 1000 platelets/μL and died after multiple hemorrhages. The second patient had 2000 platelets/μL, had melena and ecchymoses, and recovered after receiving intravenous immunoglobulin. ZIKV may be associated with immune-mediated severe thrombocytopenia.

Keywords: Puerto Rico; Zika virus; fatal; thrombocytopenia.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

Figures

Figure 1
Figure 1
Hemorrhagic manifestations in case 1. A, Computed tomography (CT) of the head without contrast enhancement demonstrating right-sided subdural hemorrhage (black arc), diffuse subarachnoid hemorrhage (arrows), subgaleal hematoma (white arc), and a 5-mm right-to-left midline shift. B, CT of the chest without contrast enhancement demonstrating diffuse alveolar hemorrhage.
See this image and copyright information in PMC

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