Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

doi:10.1093/cid/ciw353

Practice Guideline

. 2016 Sep 1;63(5):e61-e111.

doi: 10.1093/cid/ciw353. Epub 2016 Jul 14.

Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

Andre C Kalil¹, Mark L Metersky², Michael Klompas³, John Muscedere⁴, Daniel A Sweeney⁵, Lucy B Palmer⁶, Lena M Napolitano⁷, Naomi P O'Grady⁸, John G Bartlett⁹, Jordi Carratalà¹⁰, Ali A El Solh¹¹, Santiago Ewig¹², Paul D Fey¹³, Thomas M File Jr¹⁴, Marcos I Restrepo¹⁵, Jason A Roberts¹⁶, Grant W Waterer¹⁷, Peggy Cruse¹⁸, Shandra L Knight¹⁸, Jan L Brozek¹⁹

Affiliations

¹ Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha.
² Division of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington.
³ Brigham and Women's Hospital and Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
⁴ Department of Medicine, Critical Care Program, Queens University, Kingston, Ontario, Canada.
⁵ Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego.
⁶ Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, State University of New York at Stony Brook.
⁷ Department of Surgery, Division of Trauma, Critical Care and Emergency Surgery, University of Michigan, Ann Arbor.
⁸ Department of Critical Care Medicine, National Institutes of Health, Bethesda.
⁹ Johns Hopkins University School of Medicine, Baltimore, Maryland.
¹⁰ Department of Infectious Diseases, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases, University of Barcelona, Spain.
¹¹ Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, Veterans Affairs Western New York Healthcare System, New York.
¹² Thoraxzentrum Ruhrgebiet, Department of Respiratory and Infectious Diseases, EVK Herne and Augusta-Kranken-Anstalt Bochum, Germany.
¹³ Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
¹⁴ Summa Health System, Akron, Ohio.
¹⁵ Department of Medicine, Division of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center at San Antonio.
¹⁶ Burns, Trauma and Critical Care Research Centre, The University of Queensland Royal Brisbane and Women's Hospital, Queensland.
¹⁷ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
¹⁸ Library and Knowledge Services, National Jewish Health, Denver, Colorado.
¹⁹ Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

PMID: 27418577
PMCID: PMC4981759
DOI: 10.1093/cid/ciw353

Practice Guideline

Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

Andre C Kalil et al. Clin Infect Dis. 2016.

. 2016 Sep 1;63(5):e61-e111.

doi: 10.1093/cid/ciw353. Epub 2016 Jul 14.

Authors

Affiliations

¹ Department of Internal Medicine, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha.
² Division of Pulmonary and Critical Care Medicine, University of Connecticut School of Medicine, Farmington.
³ Brigham and Women's Hospital and Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
⁴ Department of Medicine, Critical Care Program, Queens University, Kingston, Ontario, Canada.
⁵ Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego.
⁶ Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, State University of New York at Stony Brook.
⁷ Department of Surgery, Division of Trauma, Critical Care and Emergency Surgery, University of Michigan, Ann Arbor.
⁸ Department of Critical Care Medicine, National Institutes of Health, Bethesda.
⁹ Johns Hopkins University School of Medicine, Baltimore, Maryland.
¹⁰ Department of Infectious Diseases, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute, Spanish Network for Research in Infectious Diseases, University of Barcelona, Spain.
¹¹ Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University at Buffalo, Veterans Affairs Western New York Healthcare System, New York.
¹² Thoraxzentrum Ruhrgebiet, Department of Respiratory and Infectious Diseases, EVK Herne and Augusta-Kranken-Anstalt Bochum, Germany.
¹³ Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
¹⁴ Summa Health System, Akron, Ohio.
¹⁵ Department of Medicine, Division of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center at San Antonio.
¹⁶ Burns, Trauma and Critical Care Research Centre, The University of Queensland Royal Brisbane and Women's Hospital, Queensland.
¹⁷ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
¹⁸ Library and Knowledge Services, National Jewish Health, Denver, Colorado.
¹⁹ Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

PMID: 27418577
PMCID: PMC4981759
DOI: 10.1093/cid/ciw353

Erratum in

Erratum.
[No authors listed] [No authors listed] Clin Infect Dis. 2017 May 1;64(9):1298. doi: 10.1093/cid/ciw799. Clin Infect Dis. 2017. PMID: 28168287 Free PMC article. No abstract available.
Erratum.
[No authors listed] [No authors listed] Clin Infect Dis. 2017 Oct 15;65(8):1435. doi: 10.1093/cid/cix587. Clin Infect Dis. 2017. PMID: 29017256 Free PMC article. No abstract available.
Erratum.
[No authors listed] [No authors listed] Clin Infect Dis. 2017 Nov 29;65(12):2161. doi: 10.1093/cid/cix759. Clin Infect Dis. 2017. PMID: 29126289 Free PMC article. No abstract available.

Abstract

It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.These guidelines are intended for use by healthcare professionals who care for patients at risk for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), including specialists in infectious diseases, pulmonary diseases, critical care, and surgeons, anesthesiologists, hospitalists, and any clinicians and healthcare providers caring for hospitalized patients with nosocomial pneumonia. The panel's recommendations for the diagnosis and treatment of HAP and VAP are based upon evidence derived from topic-specific systematic literature reviews.

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Comment in

Reply to Daniels et al.
Palmer LB, Sweeney DA, Metersky ML, Kalil AC. Palmer LB, et al. Clin Infect Dis. 2017 Feb 1;64(3):387-388. doi: 10.1093/cid/ciw727. Epub 2016 Nov 1. Clin Infect Dis. 2017. PMID: 27803095 No abstract available.
Inhaled Antibiotics for Hospital-Acquired and Ventilator-Associated Pneumonia.
Daniels LM, Juliano J, Marx A, Weber DJ. Daniels LM, et al. Clin Infect Dis. 2017 Feb 1;64(3):386-387. doi: 10.1093/cid/ciw726. Epub 2016 Nov 1. Clin Infect Dis. 2017. PMID: 27803096 No abstract available.
Telavancin in the Recent Hospital Acquired and Ventilator Associated Pneumonia (HAP/VAP) 2016 Guidelines.
Hassoun A, Friedman B, Saravolatz LD. Hassoun A, et al. Clin Infect Dis. 2017 Jun 1;64(11):1633. doi: 10.1093/cid/cix272. Clin Infect Dis. 2017. PMID: 28369192 No abstract available.
Reply to Hassoun et al.
Sweeney DA, Klompas M, Muscedere J, Metersky ML, Kalil AC. Sweeney DA, et al. Clin Infect Dis. 2017 Jun 1;64(11):1633-1634. doi: 10.1093/cid/cix275. Clin Infect Dis. 2017. PMID: 28369298 No abstract available.
The 2016 Clinical Practice Guidelines for Management of Hospital-Acquired and Ventilator-Associated Pneumonia.
Wu H, Harder C, Culley C. Wu H, et al. Can J Hosp Pharm. 2017 May-Jun;70(3):251-252. doi: 10.4212/cjhp.v70i3.1667. Epub 2017 Jun 30. Can J Hosp Pharm. 2017. PMID: 28680182 Free PMC article. No abstract available.

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References

1. American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA). Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388–416. - PubMed
1. Guyatt GH, Oxman AD, Vist GE et al. . GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924–6. - PMC - PubMed
1. US Food and Drug Administration (FDA). Information for healthcare professionals: colistimethate (marketed as Coly-Mycin M and generic products). Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPa.... Accessed September 2014.
1. Magill SS, Edwards JR, Fridkin SK;. Emerging Infections Program Healthcare-Associated Infections Antimicrobial Use Prevalence Survey Team. Survey of health care-associated infections. N Engl J Med 2014; 370:2542–3. - PubMed
1. Dudeck MA, Weiner LM, Allen-Bridson K et al. . National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Control 2013; 41:1148–66. - PMC - PubMed

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[1] American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA). Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388–416. - PubMed

[2] American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA). Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388–416. - PubMed

[3] Guyatt GH, Oxman AD, Vist GE et al. . GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924–6. - PMC - PubMed

[4] Guyatt GH, Oxman AD, Vist GE et al. . GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924–6. - PMC - PubMed

[5] US Food and Drug Administration (FDA). Information for healthcare professionals: colistimethate (marketed as Coly-Mycin M and generic products). Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPa.... Accessed September 2014.

[6] US Food and Drug Administration (FDA). Information for healthcare professionals: colistimethate (marketed as Coly-Mycin M and generic products). Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPa.... Accessed September 2014.

[7] Magill SS, Edwards JR, Fridkin SK;. Emerging Infections Program Healthcare-Associated Infections Antimicrobial Use Prevalence Survey Team. Survey of health care-associated infections. N Engl J Med 2014; 370:2542–3. - PubMed

[8] Magill SS, Edwards JR, Fridkin SK;. Emerging Infections Program Healthcare-Associated Infections Antimicrobial Use Prevalence Survey Team. Survey of health care-associated infections. N Engl J Med 2014; 370:2542–3. - PubMed

[9] Dudeck MA, Weiner LM, Allen-Bridson K et al. . National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Control 2013; 41:1148–66. - PMC - PubMed

[10] Dudeck MA, Weiner LM, Allen-Bridson K et al. . National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Control 2013; 41:1148–66. - PMC - PubMed

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Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

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Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society

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