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. 2016 Jul 15;27(14):2145-8.
doi: 10.1091/mbc.E15-10-0698.

Exploiting DNA repair defects for novel cancer therapies

Dik C van Gent  1 , Roland Kanaar  2
Affiliations

Exploiting DNA repair defects for novel cancer therapies

Dik C van Gent et al. Mol Biol Cell. .

Abstract

Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.

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