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Review
. 2016 Sep;80(3):326-38.
doi: 10.1002/ana.24730. Epub 2016 Aug 4.

Acute flaccid myelitis: A clinical review of US cases 2012-2015

Kevin Messacar  1   2 , Teri L Schreiner  3 , Keith Van Haren  4 , Michele Yang  3 , Carol A Glaser  5 , Kenneth L Tyler  6 , Samuel R Dominguez  7
Affiliations
Review

Acute flaccid myelitis: A clinical review of US cases 2012-2015

Kevin Messacar et al. Ann Neurol. 2016 Sep.

Abstract

This review highlights clinical features of the increasing cases of acute flaccid paralysis associated with anterior myelitis noted in the United States from 2012 to 2015. Acute flaccid myelitis refers to acute flaccid limb weakness with spinal cord gray matter lesions on imaging or evidence of spinal cord motor neuron injury on electrodiagnostic testing. Although some individuals demonstrated improvement in motor weakness and functional deficits, most have residual weakness a year or more after onset. Epidemiological evidence and biological plausibility support an association between enterovirus D68 and the recent increase in acute flaccid myelitis cases in the United States. Ann Neurol 2016;80:326-338.

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Conflict of interest statement

Potential Conflicts of Interest Nothing to report.

Figures

FIGURE 1
FIGURE 1
Timeline of clinical features of acute flaccid myelitis cases in the United States 2012–2015. CMAPs = compound muscle action potentials; CSF = cerebrospinal fluid; EMG = electromyography; GI = gastrointestinal; MUPs = motor unit potentials; NCV = nerve conduction velocity.
FIGURE 2
FIGURE 2
Representative magnetic resonance imaging (MRI) images of the spinal cord in acute flaccid myelitis cases in the United States 2012–2015. MRI images from acute flaccid myelitis patients in the Children’s Hospital Colorado cohort. (A and B) Saggital T2-weighted MRI sequences of the spinal cord demonstrate longitudinally extensive, hyperintense lesions. (C and D) Axial T2-weighted MRI sequences of the spinal cord demonstrate predominant involvement of the spinal cord gray matter.
See this image and copyright information in PMC

References

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    1. Pastula DM, Aliabadi N, Haynes AK, et al. Centers for Disease Control and Prevention (CDC) Acute neurologic illness of unknown etiology in children—Colorado, August–September 2014. MMWR Morb Mortal Wkly Rep. 2014;63:901–902. - PMC - PubMed
    1. Division of Viral Diseases, National Centers for Immunization and Respiratory Diseases, CDC; Division of Vector-Borne Diseases, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, CDC; Children’s Hospital Colorado; Council of State and Territorial Epidemiologists. Notes from the field: acute flaccid myelitis among persons aged ≤21 years—United States, August 1–November 13, 2014. MMWR Morb Mortal Wkly Rep. 2015;63:1243–1244. - PMC - PubMed
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