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Review
. 2016 Dec 15:107:213-227.
doi: 10.1016/j.addr.2016.07.002. Epub 2016 Jul 14.

Injectable formulations of poly(lactic acid) and its copolymers in clinical use

Anjali Jain  1 , Konda Reddy Kunduru  2 , Arijit Basu  2 , Boaz Mizrahi  3 , Abraham J Domb  4 , Wahid Khan  5
Affiliations
Review

Injectable formulations of poly(lactic acid) and its copolymers in clinical use

Anjali Jain et al. Adv Drug Deliv Rev. .

Abstract

Poly(lactic acid) and its copolymers have revolutionized the field of drug delivery due to their excellent biocompatibility and tunable physico-chemical properties. These copolymers have served the healthcare sector by contributing many products to combat various diseases and for biomedical applications. This article provides a comprehensive overview of clinically used products of poly(lactic acid) and its copolymers. Multi-dimension information covering product approval, formulation aspects and clinical status is described to provide a panoramic overview of each product. Moreover, leading patented technologies and various clinical trials on these products for different applications are included. This review focuses on marketed injectable formulations of PLA and its copolymers.

Keywords: Injectable depot; Microspheres; PLA clinical products; PLA copolymers; Poly(lactic acid).

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