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Observational Study
. 2016 Aug;48(2):212-4.
doi: 10.1016/j.ijantimicag.2016.05.010. Epub 2016 Jul 5.

Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp

S Grau  1 , S Luque  2 , D Echeverría-Esnal  2 , L Sorlí  3 , N Campillo  2 , M Montero  4 , F Álvarez Lerma  5 , V Plasencia  6 , J P Horcajada  7
Affiliations
Observational Study

Urinary micafungin levels are sufficient to treat urinary tract infections caused by Candida spp

S Grau et al. Int J Antimicrob Agents. 2016 Aug.

Abstract

Six cases of patients diagnosed with urinary tract infection (UTI) successfully treated with micafungin are reported. Four were infected with fluconazole-resistant Candida spp. and two (with hepatic injury) were infected with fluconazole-sensitive Candida spp. Traditionally, echinocandins have not been considered for the treatment of UTIs. However, despite its low urinary excretion rate, therapeutic drug monitoring of micafungin urinary levels could be helpful in order to achieve optimal pharmacokinetic/pharmacodynamic (PK/PD) indices for treating UTIs caused by Candida spp. resistant to fluconazole.

Keywords: Candida spp; Fluconazole-resistant; Micafungin; Urinary tract infection.

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