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Review
. 2016 May 30;9(1):21-30.
doi: 10.15283/ijsc.2016.9.1.21.

Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review

Sheetal Kashinath Medhekar  1 , Vikas Suresh Shende  1 , Anjali Baburao Chincholkar  1
Affiliations
Review

Recent Stem Cell Advances: Cord Blood and Induced Pluripotent Stem Cell for Cardiac Regeneration- a Review

Sheetal Kashinath Medhekar et al. Int J Stem Cells. .

Abstract

Stem cells are primitive self renewing undifferentiated cell that can be differentiated into various types of specialized cells like nerve cell, skin cells, muscle cells, intestinal tissue, and blood cells. Stem cells live in bone marrow where they divide to make new blood cells and produces peripheral stem cells in circulation. Under proper environment and in presence of signaling molecules stem cells begin to develop into specialized tissues and organs. These unique characteristics make them very promising entities for regeneration of damaged tissue. Day by day increase in incidence of heart diseases including left ventricular dysfunction, ischemic heart disease (IHD), congestive heart failure (CHF) are the major cause of morbidity and mortality. However infracted tissue cannot regenerate into healthy tissue. Heart transplantation is only the treatment for such patient. Due to limitation of availability of donor for organ transplantation, a focus is made for alternative and effective therapy to treat such condition. In this review we have discussed the new advances in stem cells such as use of cord stem cells and iPSC technology in cardiac repair. Future approach of CB cells was found to be used in tissue repair which is specifically observed for improvement of left ventricular function and myocardial infarction. Here we have also focused on how iPSC technology is used for regeneration of cardiomyocytes and intiating neovascularization in myocardial infarction and also for study of pathophysiology of various degenerative diseases and genetic disease in research field.

Keywords: Cardiac regeneration; Myocardial infarction; Stem cells; Umbilical cord blood; iPSC technology.

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Figures

Fig. 1
Fig. 1
Schematic presentation of different sources of stem cells.
Fig. 2
Fig. 2
Differentiation of Embryonic stem cells into various cells.
Fig. 3
Fig. 3
The umbilical cord arranged in a helical structure.
Fig. 4
Fig. 4
Paracrine effect of MSC in cardiac repair (31, 32).
Fig. 5
Fig. 5
Regeneration of myocardial tissue (45).
Fig. 6
Fig. 6
Cardiomyocyte differentiation from IPS cells (49, 50).
Fig. 7
Fig. 7
Stem cell based cardiac regeneration (49, 50).
See this image and copyright information in PMC

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