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. 2014 Sep 30;2(4):417-28.
doi: 10.3390/healthcare2040417.

Negative Pressure Wound Therapy on Surgical Site Infections in Women Undergoing Elective Caesarean Sections: A Pilot RCT

Wendy Chaboyer  1 , Vinah Anderson  2 , Joan Webster  3   4 , Anne Sneddon  5 , Lukman Thalib  6 , Brigid M Gillespie  7
Affiliations

Negative Pressure Wound Therapy on Surgical Site Infections in Women Undergoing Elective Caesarean Sections: A Pilot RCT

Wendy Chaboyer et al. Healthcare (Basel). .

Abstract

Obese women undergoing caesarean section (CS) are at increased risk of surgical site infection (SSI). Negative Pressure Wound Therapy (NPWT) is growing in use as a prophylactic approach to prevent wound complications such as SSI, yet there is little evidence of its benefits. This pilot randomized controlled trial (RCT) assessed the effect of NPWT on SSI and other wound complications in obese women undergoing elective caesarean sections (CS) and also the feasibility of conducting a definitive trial. Ninety-two obese women undergoing elective CS were randomized in theatre via a central web based system using a parallel 1:1 process to two groups i.e., 46 women received the intervention (NPWT PICO™ dressing) and 46 women received standard care (Comfeel Plus(®) dressing). All women received the intended dressing following wound closure. The relative risk of SSI in the intervention group was 0.81 (95% CI 0.38-1.68); for the number of complications excluding SSI it was 0.98 (95% CI 0.34-2.79). A sample size of 784 (392 per group) would be required to find a statistically significant difference in SSI between the two groups with 90% power. These results demonstrate that a larger definitive trial is feasible and that careful planning and site selection is critical to the success of the overall study.

Keywords: NPWT; caesarean section; obesity; surgical site infection.

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Figures

Figure 1
Figure 1
Participant Flow Diagram.
Figure 2
Figure 2
Power Curve.
See this image and copyright information in PMC

References

    1. World Health Organization 10 Facts on Safe Surgery. [(accessed on 15 August 2014)]. Available online: http://www.who.int/topics/patient_safety/en/
    1. Australia’s Hospitals 2008–2009—At a Glance. Australian Institute of Health and Welfare; Canberra, Australia: 2010.
    1. Mangram A.J., Horan T.C., Pearson M.L., Silver L.C., Jarvis W.R. Guideline for prevention of surgical site infection, 1999. Infect. Control Hosp. Epidemiol. 1999;20:247–280. - PubMed
    1. Anderson D.J. Surgical site infections. Infect. Dis. Clin. 2011;25:135–153. doi: 10.1016/j.idc.2010.11.004. - DOI - PubMed
    1. Graves N., Halton K., Curtis M., Doidge S., Lairson D., McLaws M., Whitby M. Costs of surgical site infections that appear after hospital discharge. Emerg. Infect. Dis. 2006;12:831–834. doi: 10.3201/eid1205.051321. - DOI - PMC - PubMed

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