Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Jun 14;37(6):458-63.
doi: 10.3760/cma.j.issn.0253-2727.2016.06.003.

[Comparisons of occurrence and curative effect of interstitial pneumonia after the related HLA-haploidentical and HLA-matched sibling peripheral blood hematopoietic stem cell transplantation]

[Article in Chinese]
X Y Wang  1 , M Jiang, J H Qu, X L Duan, H L Yuan, L Wang, J L Xu, L L Ding, Crimea Nadia Abdul, L Li, Arsene Eed, X H Guo, B Z Wen
Affiliations
Comparative Study

[Comparisons of occurrence and curative effect of interstitial pneumonia after the related HLA-haploidentical and HLA-matched sibling peripheral blood hematopoietic stem cell transplantation]

[Article in Chinese]
X Y Wang et al. Zhonghua Xue Ye Xue Za Zhi. .

Abstract
in English, Chinese

Objective: To compare occurrence and curative effect of interstitial pneumonia (IP) of patients with malignant hematologic disease after related HLA-haploidentical peripheral blood stem cell transplantation without T-cell depletion (RHNT-PBSCT) and non T cell-depleted HLA-matched sibling peripheral blood stem cell transplantation (MSNT-PBSCT).

Methods: 109 patients with malignant hematologic disease as the research cases received RHNT-PBSCT from January 2006 to December 2014, which were compared with 125 patients treated with MSNT-PBSCT during the same period to determine the occurrence of IP and curative effect produced by ganciclovir and joint adrenal glucocorticoids.

Results: The incidences of IP in RHNT-PBSCT and MSNT-PBSCT groups were 15.60%(17/109) and 13.60%(17/125) (P=0.150), respectively; both the effective rates were 76.47%(13/17) (P=0.536), the difference was not statistically significant. Single factor analysis showed that acute graft versus host disease was a risk factor for the occurrence of IP after RHNT-PBSCT (P=0.001).

Conclusion: The incidence of IP in patients with malignant hematologic disease after RHNT-PBSCT didn' t increase when compared with patients after MSNT-PBSCT. The curative effects of the two groups were equivalent after priority to ganciclovir and joint adrenal glucocorticoids.

目的: 比较恶性血液病患者行亲缘HLA单倍体相合非体外去T细胞外周血造血干细胞移植（RHNT-PBSCT）与同胞HLA全相合非体外去T细胞（MSNT）-PBSCT术后间质性肺炎的发生率及其疗效。

方法: 以2006年1月至2014年12月行RHNT-PBSCT术的109例恶性血液病患者为研究对象，以同期行MSNT-PBSCT术的125例患者为对照，对两组患者间质性肺炎的发生情况和采用更昔洛韦为主联合肾上腺糖皮质激素治疗后的疗效进行比较研究。

结果: RHNT-PBSCT和MSNT-PBSCT患者组间质性肺炎发生率分别为15.60%（17/109）、13.60%（17/125）（P=0.150），治疗有效率均为76.47%（13/17）（P=0.536），差异均无统计学意义。单因素分析结果显示急性移植物抗宿主病是影响RHNT-PBSCT术后发生间质性肺炎的危险因素（P=0.001）。

结论: 行RHNT-PBSCT术后的恶性血液病患者，与行MSNT-PBSCT术后的患者比较，间质性肺炎的发生率并不增高，采用更昔洛韦为主联合肾上腺糖皮质激素治疗后两组疗效相当。

PubMed Disclaimer

Figures

图1
图1. 亲缘HLA单倍体相合非体外去T细胞（RHNT）和同胞HLA全相合非体外去T细胞（MSNT）外周血造血干细患者总生存曲线率
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. 袁 海龙, 江 明, 温 丙昭, et al. HLA单倍体相合与全相合外周血造血干细胞移植治疗恶性血液病的疗效比较[J] 中华器官移植杂志. 2010;31(2):79–83. doi: 10.3760/cma.j.issn.0254-1785.2010.02.006. - DOI
    1. 吴 德沛, 孙 爱宁. 临床造血干细胞移植[M] 合肥: 安徽科学技术出版社; 2010. pp. 297–306.
    1. 边 绿斐, 陈 少贤. 造血干细胞移植的肺部并发症[J] 国际内科学杂志. 2007;34(2):81–84.
    1. 许 兰平, 黄 晓军, 郭 乃榄, et al. 聚合酶链反应方法检测造血干细胞移植患者巨细胞病毒感染状况[J] 中华血液学杂志. 2003;24(8):407–409. - PubMed
    1. 陈 欢, 刘 开彦, 许 兰平, et al. 异基因造血干细胞移植后实时定量聚合酶链反应在巨细胞病毒感染诊断和治疗中的应用[J] 中华血液学杂志. 2009;30(2):77–81. doi: 10.3760/cma.j.issn.0253-2727.2009.02.002. - DOI

Publication types

MeSH terms