Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

doi:10.1128/AAC.01319-16

. 2016 Sep 23;60(10):6356-8.

doi: 10.1128/AAC.01319-16. Print 2016 Oct.

Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

Jose F Delgado-Blas¹, Cristina M Ovejero¹, Lorena Abadia-Patiño², Bruno Gonzalez-Zorn³

Affiliations

¹ Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
² Department of Biomedicine, Instituto de Investigaciones en Biomedicina y Ciencias Aplicadas, Universidad de Oriente, Cumana, Venezuela.
³ Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain bgzorn@ucm.es.

PMID: 27431212
PMCID: PMC5038285
DOI: 10.1128/AAC.01319-16

Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

Jose F Delgado-Blas et al. Antimicrob Agents Chemother. 2016.

. 2016 Sep 23;60(10):6356-8.

doi: 10.1128/AAC.01319-16. Print 2016 Oct.

Authors

Jose F Delgado-Blas¹, Cristina M Ovejero¹, Lorena Abadia-Patiño², Bruno Gonzalez-Zorn³

Affiliations

¹ Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain.
² Department of Biomedicine, Instituto de Investigaciones en Biomedicina y Ciencias Aplicadas, Universidad de Oriente, Cumana, Venezuela.
³ Department of Animal Health and Centro de Vigilancia Sanitaria Veterinaria, Universidad Complutense de Madrid, Madrid, Spain bgzorn@ucm.es.

PMID: 27431212
PMCID: PMC5038285
DOI: 10.1128/AAC.01319-16

Abstract

We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.

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References

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1. World Health Organization. 2011. Critically important antimicrobial agents for human medicine, 3rd ed World Health Organization, Geneva, Switzerland.
1. Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A, Jukes H, Liebana E, Lopez Navas A, Mackay D, Magiorakos AP, Moreno Romo MA, Moulin G, Muñoz Madero C, Matias Ferreira Pomba MC, Powell M, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall EJ, Törneke K, van Duijkeren E, Torren Edo J. 2015. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents 46:297–306. doi:10.1016/j.ijantimicag.2015.06.005. - DOI - PubMed
1. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–168. doi:10.1016/S1473-3099(15)00424-7. - DOI - PubMed
1. Skov RL, Monnet DL. 2016. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill 21(9):pii=30155 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21403. - PubMed

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[1] Rossolini GM. 2015. Extensively drug-resistant carbapenemase-producing Enterobacteriaceae: an emerging challenge for clinicians and healthcare systems. J Intern Med 277:528–531. doi:10.1111/joim.12350. - DOI - PubMed

[2] Rossolini GM. 2015. Extensively drug-resistant carbapenemase-producing Enterobacteriaceae: an emerging challenge for clinicians and healthcare systems. J Intern Med 277:528–531. doi:10.1111/joim.12350. - DOI - PubMed

[3] World Health Organization. 2011. Critically important antimicrobial agents for human medicine, 3rd ed World Health Organization, Geneva, Switzerland.

[4] World Health Organization. 2011. Critically important antimicrobial agents for human medicine, 3rd ed World Health Organization, Geneva, Switzerland.

[5] Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A, Jukes H, Liebana E, Lopez Navas A, Mackay D, Magiorakos AP, Moreno Romo MA, Moulin G, Muñoz Madero C, Matias Ferreira Pomba MC, Powell M, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall EJ, Törneke K, van Duijkeren E, Torren Edo J. 2015. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents 46:297–306. doi:10.1016/j.ijantimicag.2015.06.005. - DOI - PubMed

[6] Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A, Jukes H, Liebana E, Lopez Navas A, Mackay D, Magiorakos AP, Moreno Romo MA, Moulin G, Muñoz Madero C, Matias Ferreira Pomba MC, Powell M, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall EJ, Törneke K, van Duijkeren E, Torren Edo J. 2015. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents 46:297–306. doi:10.1016/j.ijantimicag.2015.06.005. - DOI - PubMed

[7] Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–168. doi:10.1016/S1473-3099(15)00424-7. - DOI - PubMed

[8] Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–168. doi:10.1016/S1473-3099(15)00424-7. - DOI - PubMed

[9] Skov RL, Monnet DL. 2016. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill 21(9):pii=30155 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21403. - PubMed

[10] Skov RL, Monnet DL. 2016. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill 21(9):pii=30155 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21403. - PubMed

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Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

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Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

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