Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 23;60(10):6356-8.
doi: 10.1128/AAC.01319-16. Print 2016 Oct.

Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

Jose F Delgado-Blas  1 , Cristina M Ovejero  1 , Lorena Abadia-Patiño  2 , Bruno Gonzalez-Zorn  3
Affiliations

Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela

Jose F Delgado-Blas et al. Antimicrob Agents Chemother. .

Abstract

We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.

PubMed Disclaimer

References

    1. Rossolini GM. 2015. Extensively drug-resistant carbapenemase-producing Enterobacteriaceae: an emerging challenge for clinicians and healthcare systems. J Intern Med 277:528–531. doi:10.1111/joim.12350. - DOI - PubMed
    1. World Health Organization. 2011. Critically important antimicrobial agents for human medicine, 3rd ed World Health Organization, Geneva, Switzerland.
    1. Catry B, Cavaleri M, Baptiste K, Grave K, Grein K, Holm A, Jukes H, Liebana E, Lopez Navas A, Mackay D, Magiorakos AP, Moreno Romo MA, Moulin G, Muñoz Madero C, Matias Ferreira Pomba MC, Powell M, Pyörälä S, Rantala M, Ružauskas M, Sanders P, Teale C, Threlfall EJ, Törneke K, van Duijkeren E, Torren Edo J. 2015. Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): development of resistance in animals and possible impact on human and animal health. Int J Antimicrob Agents 46:297–306. doi:10.1016/j.ijantimicag.2015.06.005. - DOI - PubMed
    1. Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH, Shen J. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis 16:161–168. doi:10.1016/S1473-3099(15)00424-7. - DOI - PubMed
    1. Skov RL, Monnet DL. 2016. Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds. Euro Surveill 21(9):pii=30155 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=21403. - PubMed

LinkOut - more resources