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. 2016 Sep 23;60(10):6362-4.
doi: 10.1128/AAC.00764-16. Print 2016 Oct.

Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying blaGES-5 from Guangzhou, China

Ding-Qiang Chen  1 , Ai-Wu Wu  2 , Ling Yang  3 , Dan-Hong Su  3 , Yong-Ping Lin  3 , Yan-Wei Hu  4 , Lei Zheng  4 , Qian Wang  5
Affiliations

Emergence and Plasmid Analysis of Klebsiella pneumoniae KP01 Carrying blaGES-5 from Guangzhou, China

Ding-Qiang Chen et al. Antimicrob Agents Chemother. .

Abstract

Klebsiella pneumoniae strain KP01 carrying blaGES-5 was identified from a patient in Guangzhou, China. High-throughput sequencing assigned blaGES-5 to a 28.5-kb nonconjugative plasmid, pGES-GZ. A 13-kb plasmid backbone sequence on pGES-GZ was found to share high sequence identities with plasmids from Gram-negative nonfermenters. A novel class 1 integron carrying a gene cassette array of orf28-orf28-blaGES-5 was identified on pGES-GZ, within which orf28 encoded a hypothetical protein possibly correlated to fosfomycin resistance.

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Figures

FIG 1
FIG 1
Genetic map of pGES-GZ and comparative analysis of its sequence with that of pNOR-2000. The 13-kb plasmid backbone regions on pNOR-2000 and pGES-GZ are shaded. The attc and attI sequences of the class 1 integron are indicated by black and white circles, respectively. Please note that for pGES-GZ, nine predicted coding sequences are not shown.
See this image and copyright information in PMC

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