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Review
. 2016 Aug;42(3):419-34.
doi: 10.1016/j.rdc.2016.03.002. Epub 2016 Jun 21.

Autoantibodies in Sjögren's Syndrome

Anum Fayyaz  1 , Biji T Kurien  1 , R Hal Scofield  2
Affiliations
Review

Autoantibodies in Sjögren's Syndrome

Anum Fayyaz et al. Rheum Dis Clin North Am. 2016 Aug.

Abstract

We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.

Keywords: Autoantibodies; Congenital heart block; Sjögren’s syndrome.

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Supplementary concepts