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Review
. 2016 Aug;42(3):449-56.
doi: 10.1016/j.rdc.2016.03.004. Epub 2016 Jun 21.

The Proteomics of Saliva in Sjögren's Syndrome

Stergios Katsiougiannis  1 , David T W Wong  2
Affiliations
Review

The Proteomics of Saliva in Sjögren's Syndrome

Stergios Katsiougiannis et al. Rheum Dis Clin North Am. 2016 Aug.

Abstract

One of the main characteristics of primary Sjögren's syndrome (pSS) is chronic dysfunction and destruction of the salivary and lacrimal glands; their secretory biofluids should reflect the glandular biological status. Saliva is a heterogeneous biofluid comprised of biomolecules and omics constituents that are altered in response to various diseases. Scientific effort has evaluated saliva proteome to diagnose, monitor, and prognosticate pSS. This article reviews the recent advances in salivary proteomics in the context of pSS, highlighting the most significant and promising findings. Determining saliva as a credible means of early disease detection could lead to translational advantages and significant clinical opportunities for pSS.

Keywords: Biomarkers; Proteomics; Saliva; Saliva diagnostics; Sjögren's syndrome.

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