Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Fred K L Spijkervet¹, Erlin Haacke², Frans G M Kroese³, Hendrika Bootsma³, Arjan Vissink⁴

Affiliations

¹ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: f.k.l.spijkervet@umcg.nl.
² Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
³ Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
⁴ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

PMID: 27431350
DOI: 10.1016/j.rdc.2016.03.007

Review

Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Fred K L Spijkervet et al. Rheum Dis Clin North Am. 2016 Aug.

. 2016 Aug;42(3):485-99.

doi: 10.1016/j.rdc.2016.03.007. Epub 2016 Jun 21.

Authors

Fred K L Spijkervet¹, Erlin Haacke², Frans G M Kroese³, Hendrika Bootsma³, Arjan Vissink⁴

Affiliations

¹ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: f.k.l.spijkervet@umcg.nl.
² Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
³ Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
⁴ Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.

PMID: 27431350
DOI: 10.1016/j.rdc.2016.03.007

Abstract

Salivary gland biopsy is a technique broadly applied for the diagnosis of Sjögren syndrome (SS), lymphoma in SS, and connective tissue disorders (sarcoidosis, amyloidosis). In SS characteristic histology findings are found, including lymphocytic infiltration surrounding the excretory ducts in combination with destruction of acinar tissue. In this article the main techniques are described for taking labial and parotid salivary gland biopsies with respect to their advantages, postoperative complications, and usefulness for diagnostic procedures, monitoring disease progression, and evaluation of treatment.

Keywords: Biopsy; Diagnostics; Labial gland; Parotid gland; Salivary gland; Sjögren syndrome.

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Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Affiliations

Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome

Authors

Affiliations

Abstract

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MeSH terms

LinkOut - more resources

Full Text Sources

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