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Editorial
. 2016 Sep;68(3):542-3.
doi: 10.1161/HYPERTENSIONAHA.116.07938. Epub 2016 Jul 18.

Small Potassium Channels: Speculation on a Role to Regulate Aldosterone Production and Blood Pressure

Wanzhu Tu  1 , J Howard Pratt  2
Affiliations
Editorial

Small Potassium Channels: Speculation on a Role to Regulate Aldosterone Production and Blood Pressure

Wanzhu Tu et al. Hypertension. 2016 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Aldosterone (Aldo) production and selectivity of K+ channels for K+ in zona glomerulosa (ZG) cells. A. The normal conduction of K+ ions from a high intracellular concentration to a much lower extracellular concentration. The unidirectional conducdance results in a highly polarized negative membrane potential (MP) and a sustained production of Aldo. B. A loss of selectivity for K+ allows Na+ to be conducted but in the opposite direction, from its high extracellular concentration to its low intracellular concentration. Na+ moving from outside to inside the cell reduces MP, increases the concentration of Ca++ which then increases synthesis and secretion of aldosterone.
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