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. 2016 Jun 7;8(6):e633.
doi: 10.7759/cureus.633.

The Prognostic Impact of Molecular Subtypes and Very Young Age on Breast Conserving Surgery in Early Stage Breast Cancer

Cetin Ordu  1 , Kandace McGuire  2 , Gul Alco  3 , Kezban Nur Pilanci  4 , Ulkuhan I Koksal  4 , Filiz Elbüken  5 , Zeynep Erdogan  6 , Filiz Agacayak  7 , Serkan Ilgun  8 , Dauren Sarsenov  8 , Alper Öztürk  8 , Şefik İğdem  3 , Sait Okkan  3 , Yeşim Eralp  9 , Maktav Dincer  3 , Vahit Ozmen  10
Affiliations

The Prognostic Impact of Molecular Subtypes and Very Young Age on Breast Conserving Surgery in Early Stage Breast Cancer

Cetin Ordu et al. Cureus. .

Abstract

Background: Premenopausal breast cancer with a triple-negative phenotype (TNBC) has been associated with inferior locoregional recurrence free survival (LRFS) and overall survival (OS) after breast conserving surgery (BCS). The aim of this study is to analyze the association between age, subtype, and surgical treatment on survival in young women (≤40 years) with early breast cancer in a population with a high rate of breast cancer in young women.

Methods: Three hundred thirty-two patients ≤40 years old with stage I-II invasive breast cancer who underwent surgery at a single institution between 1998 and 2012 were identified retrospectively. Uni- and multivariate analysis evaluated predictors of LRFS, OS, and disease free survival (DFS).

Results: Most patients (64.2%) underwent BCS. Mean age and follow-up time were 35 (25 ± 3.61) years, and 72 months (range, 24-252), respectively. In multivariate analysis, multicentricity/multifocality and young age (<35 years) independently predicted for poorer DFS and OS. Those aged 35-40 years had higher LRFS and DFS than those <35 in the mastectomy group (p=0.007 and p=0.039, respectively). Patients with TNBC had lower OS compared with patients with luminal A subtype (p=0.042), and those who underwent BCS had higher OS than patients after mastectomy (p=0.015).

Conclusion: Young age (< 35 years) is an independent predictor of poorer OS and DFS as compared with ages 35-40, even in countries with a lower average age of breast cancer presentation. In addition, TNBC in the young predicts for poorer OS. BCS can be performed in young patients with TNBC, despite their poorer overall survival.

Keywords: breast cancer; breast conserving surgery; molecular subtypes; survival; young age.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Breast Cancer Outcomes by Age
Younger patients had lower LRFS and DFS rates than the older age group (<35 years vs 35–40 years).
Figure 2
Figure 2. Overall Survival by Molecular Subtypes
Triple negative breast cancer patients (TNBC) had significantly lower OS than luminal-A subtype.
See this image and copyright information in PMC

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References

    1. Parkin DM, Bray FI, Devesa SS. Eur J Cancer. Vol. 37. Cancer; 2001. Cancer burden in the year 2000. The global picture; pp. 4–66. - PubMed
    1. Recent trends in breast cancer among younger women in the United States. Brinton LA, Sherman ME, Carreon JD, Anderson WF. J Natl Cancer Inst. 2008;100:1643–1648. - PMC - PubMed
    1. Vahit Ozmen. Breast. Istanbul-Turkey: Yelken Basim Yayin Sanayi ve Ticaret Limited; 2013. Breast Cancer in Turkey.
    1. Breast cancer in young women: poor survival despite intensive treatment. Fredholm H, Eaker S, Frisell J, Holmberg L, Fredriksson I, Lindman H. PLoS One. 2009;11:7695. - PMC - PubMed
    1. Young age: an independent risk factor for disease-free survival in women with operable breast cancer. Han W, Kim SW, Park IA, Kang D, Kim SW, Youn YK, Oh SK, Choe KJ, Noh DY. BMC Cancer. 2004;4:82. - PMC - PubMed

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