. 2014 Nov 10:2014:659410.

doi: 10.1155/2014/659410. eCollection 2014.

Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents

Affiliations

¹ Children's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9; Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5.
² Department of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada N6A 5A5.
³ School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
⁴ Children's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.
⁵ Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5.

PMID: 27433488
PMCID: PMC4897295
DOI: 10.1155/2014/659410

Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents

Cheril L Clarson et al. Int Sch Res Notices. 2014.

. 2014 Nov 10:2014:659410.

doi: 10.1155/2014/659410. eCollection 2014.

Authors

Affiliations

¹ Children's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9; Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5.
² Department of Epidemiology & Biostatistics, University of Western Ontario, London, ON, Canada N6A 5A5.
³ School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
⁴ Children's Hospital, London Health Sciences Centre, P.O. Box 5010, London, ON, Canada N6A 5W9.
⁵ Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5.

PMID: 27433488
PMCID: PMC4897295
DOI: 10.1155/2014/659410

Abstract

Objective. To assess a comprehensive, intensive lifestyle intervention in combination with metformin extended release (MXR) or placebo on body mass index (BMI) and risk factors for type 2 diabetes and cardiovascular disease in obese adolescents. Study Design. Sixty-nineobese adolescents (mean BMI 32.5) received a comprehensive lifestyle intervention with structured dietary, physical activity, and behavioral components for 24 months. Subjects were randomized to 1 of 4 groups: MXR (33) 2,000 mg daily or placebo, with either moderate or vigorous intensity exercise for the first 3 months. Subsequently the exercise intervention was the same for all 4 groups. Results. Anthropometry measurements did not differ with initial exercise intensity at any time. At 3 months % body fat decreased in all 4 groups (P < 0.006). BMI and % body fat decreased in the MXR groups, but not the placebo groups, at 6 (-0.88, -3.16) and 12 months (-0.56, -2.34) (P < 0.05). Insulin resistance, fasting blood glucose, and leptin improved in all groups at 6 and 12 months. A high subject attrition rate (58%) occurred by 24 months. Conclusion. A comprehensive, intensive lifestyle intervention combined with MXR led to a decline in BMI and % body fat at 1 year independent of initial exercise intensity. This trial is registered with ClinicalTrials.gov NCT00934570 .

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Figures

**Figure 1**
Lifestyle intervention components—frequency and duration.

**Figure 2**
Flow chart for screening, enrollment, randomization, and follow-up of study participants.

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Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents

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Effects of a Comprehensive, Intensive Lifestyle Intervention Combined with Metformin Extended Release in Obese Adolescents

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