Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jun;256(3):601-5.
doi: 10.1007/BF00225610.

Effect of phlebotomy on the ferritin iron content in the rat liver as determined morphometrically with the use of electron energy loss spectroscopy

M I Cleton  1 , L J Mostert, L W Sorber, A A de Jong, C M de Jeu-Jaspars, W C de Bruijn
Affiliations

Effect of phlebotomy on the ferritin iron content in the rat liver as determined morphometrically with the use of electron energy loss spectroscopy

M I Cleton et al. Cell Tissue Res. 1989 Jun.

Abstract

Phlebotomy of untreated and iron-loaded rats results in a significant decrease in total liver iron. In iron-loaded rats a marked decrease in iron-containing particles is observed ultrastructurally in lysosomes and cytoplasm of hepatic sinusoidal cells but not in parenchymal cells. This remarkable phenomenon was further investigated in a morphometric study, based on element-specific (iron) distribution images made in situ in the parenchymal cell by means of electron energy loss spectroscopy. With the use of this technique it could be shown that in spite of phlebotomy the ferritin iron content of the iron-loaded liver parenchymal cell is not decreased.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Biol Met. 1988;1(1):33-42 - PubMed
    1. Br J Haematol. 1981 Dec;49(4):593-602 - PubMed
    1. Prog Biophys Mol Biol. 1980;36(2-3):56-86 - PubMed
    1. J Ultrastruct Res. 1980 Sep;72(3):336-48 - PubMed
    1. J Submicrosc Cytol. 1981 Jul;13(3):455-64 - PubMed