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Case Reports
. 2016 Jul 19:16:99.
doi: 10.1186/s12887-016-0628-4.

Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma

Maria Debora De Pasquale  1 , Angela Mastronuzzi  2 , Luigi De Sio  2 , Annalisa Serra  2 , Chiara Grimaldi  3 , Marcello Chinali  4 , Ugo Giordano  4
Affiliations
Case Reports

Transient global ventricular dysfunction in an adolescent affected by pancreatic adenocarcinoma

Maria Debora De Pasquale et al. BMC Pediatr. .

Abstract

Background: Takotsubo cardiomyopathy (TC) is characterized by a transient decrease in ejection fraction and a reversible left ventricular dysfunction. The pathophysiology of TC is not completely understood. Heterogeneous and multifactorial mechanisms are involved: drugs, emotional and physical stress, genetic and hormonal factors.

Case presentation: A 17 year-old male with metastatic pancreatic adenocarcinoma, under chemotherapy containing 5-fluorouracil, presented severe left ventricular dysfunction requiring mechanical ventilation and inotropes administration. He completely recovered in 2 weeks.

Conclusion: To our knowledge this is the first report of transient form of ventricular dysfunction, mimicking TC, in an adolescent. We believe that children and adolescents receiving 5-fluorouracil should be closely monitored and referred for investigation if they develop cardiac symptoms.

Keywords: Pancreatic carcinoma; Pediatrics; Reversible left ventricular dysfunction; Takotsubo cardiomyopathy.

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