Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr 9;32(2):90-2.
doi: 10.5152/UCD.2015.2886. eCollection 2016.

Colonic mucosal pseudolipomatosis: Are we aware of it?

Feyzullah Ersöz  1 , Ahmet Burak Toros  2 , Ekrem Çakar  1 , Mehmet Emin Güneş  1 , Serdar Çulcu  1 , Serkan Sarı  1 , Aziz Arı  1 , Esra Paşaoğlu  3 , Nevra Dursun  3
Affiliations

Colonic mucosal pseudolipomatosis: Are we aware of it?

Feyzullah Ersöz et al. Ulus Cerrahi Derg. .

Abstract

Objective: Colonic mucosal pseudolipomatosis is rare, and its pathogenesis is controversial. A number of mechanisms, including mechanical injury during an endoscopic procedure or chemical injury by disinfectant, seem to contribute to its pathogenesis.

Material and methods: This retrospective study examined the colonic biopsies of 1370 patients. These biopsies were preserved at the Department of Pathology of Istanbul Training and Research Hospital between January 2012 and June 2013.

Results: We found pseudolipomatosis in 14 of 1370 colonoscopy cases (1.02%). Of these 14 patients, 8 were male and 6 were female. The male patients were between 24 and 66 years, with a mean of 39; the female patients were between 26 and 58 years, with a mean of 42.

Conclusion: Many endoscopists are unaware of the lesion, and the diagnosis is generally possible only after pathological assessment of multiple biopsies taken from suspect lesions. Here we report and discuss colonic pseudolipomatosis incidentally found in a series of patients undergoing routine colonoscopy, and we underline the endoscopic pattern and diagnostic difficulties.

Keywords: Pseudolipomatosis; colonoscopy; disinfectant; mucosal injury.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
An endoscopic appearance of colonic pseudolipo-matosis
Figure 2.
Figure 2.
Vacuolar structures in the lamina propria of colonic mucosa, indicative of fatty tissue (HE ×40)
See this image and copyright information in PMC

References

    1. Snover DC, Sandstad J, Hutton S. Mucosal pseudolipomatosis of the colon. Am J Clin Pathol. 1985;84:575–580. - PubMed
    1. Waring JP, Manne RK, Wadas DD, Sanowski RA. Mucosal pseudolipomatosis: An air pressure-related colonoscopy complication. Gastrointest Endosc. 1989;35:93–94. http://dx.doi.org/10.1016/S0016-5107(89)72716-4. - DOI - PubMed
    1. Kim SJ, Baek IH. Colonic mucosal pseudolipomatosis: Disinfectant colitis ? Gastroenterol Nurs. 2012;35:208–213. http://dx.doi.org/10.1097/SGA.0b013e3182562bde. - DOI - PubMed
    1. Cammarota G, Cesaro P, Cazzato A, Fedeli P, Riccioni ME, Sparano L, et al. Hydrogen peroxide-related colitis (previously known as “pseudolipomatosis”): a series of cases occurring in an epidemic pattern. Endoscopy. 2007;39:916–919. http://dx.doi.org/10.1055/s-2007-966652. - DOI - PubMed
    1. Lapeyre B. The ‘frost sign’ and the ‘snow white sign’: Intramucosal air injection or peroxide colitis? Endoscopy. 2005;37:679. http://dx.doi.org/10.1055/s-2005-861332. - DOI - PubMed

LinkOut - more resources