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. 2016 Jul;32(3):195-205.
doi: 10.5487/TR.2016.32.3.195. Epub 2016 Jul 30.

Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences

Sang-Yong Eom  1 , Ji-Ae Lim  2 , Yong-Dae Kim  1 , Byung-Sun Choi  3 , Myung Sil Hwang  4 , Jung-Duck Park  3 , Heon Kim  1 , Ho-Jang Kwon  2
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Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences

Sang-Yong Eom et al. Toxicol Res. 2016 Jul.

Abstract

This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index (F ST), respectively. The Korean population was genetically similar to the CHB and JPT populations (F ST < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation (F ST > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest F ST value between the Korean and African populations was cystathionine-β-synthase rs234709 (F ST: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

Keywords: Gene frequency; Genetic diversity; Metals; Single nucleotide polymorphism.

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Figures

Fig. 1
Fig. 1
Genetic differentiation between Korean and other ethnic populations. A: Korean versus Chinese (CHB). B: Korean versus Japanese (JPT). C: Korean versus Caucasian (CEU). D: Korean versus African (YIR).
See this image and copyright information in PMC

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References

    1. Jarup L. Hazards of heavy metal contamination. Br Med Bull. 2003;68:167–82. doi: 10.1093/bmb/ldg032. - DOI - PubMed
    1. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. EXS. 2012;101:133–164. - PMC - PubMed
    1. Christensen JM. Human exposure to toxic metals: factors influencing interpretation of biomonitoring results. Sci Total Environ. 1995;166:89–135. doi: 10.1016/0048-9697(95)04478-J. - DOI - PubMed
    1. Goyer RA. Nutrition and metal toxicity. Am J Clin Nutr. 1995;61:646S–650S. - PubMed
    1. Nordberg GF, Fowler BA, Nordberg M. Handbook on the Toxicology of Metals. Academic Press; 2014.

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