Molecular Characterization of Clear Cell Lesions of Head and Neck

Abstract

The salivary glands, oral mucosa and jaws constitute a group of lesions which are heterogeneous in nature and are odontogenic, salivary or metastatic in origin. This group of tumours is termed as Clear Cell Tumours. Fixation artifacts are one of the most important reasons for the cell to appear clear but clearing of cells may also result from cytoplasmic accumulation of water, presence of glycogen within the cell, intermediate filaments, immature zymogen granules, or a paucity of cellular organelles. Clear cell Odontogenic neoplasms predominantly include odontogenic carcinoma, ameloblastoma and calcifying epithelial odontogenic tumour. Clear cell tumours of salivary gland origin are almost invariably malignant in nature but they do include two benign lesions. Very frequently, surgical pathologist encounters clear cells in many malignant neoplasms, the nature and sources of which are undetermined on the basis of conventional histopathology. This review will selectively discuss the clinicopathological features of neoplasms which at times may pose a diagnostic challenge and dilemma due to clear cell changes.

Keywords: Artifact; Fixation; Metastatic; Odontogenic; Salivary.

[Table/Fig-2]:

Histopathological picture showing nests of clear cells surrounded by hyalinized band at X400 magnification (black arrow). (This picture is of my slide).

[Table/Fig-3]:

Histopathological picture shows areas of clear cells which are large polygonal and having distinct outline X400 magnification (black arrow). (This picture is of my slide).

[Table/Fig-4]:

Islands of clear cells with foci of calcification. (H&E stain, 10x) [18].

[Table/Fig-5]:

Islands of clear cells which are large polygonal in shape with distinct outline (black arrow) [19].