Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Dec 24:2014:820921.
doi: 10.1155/2014/820921. eCollection 2014.

Characteristics of Primary Cutaneous T-Cell Lymphoma in Iran: A 10-Year Retrospective Study

Farahnaz Fatemi Naeini  1 , Hamidreza Sadeghiyan  2 , Mohsen Pourazizi  3 , Jamshid Najafian  4 , Bahareh Abtahi-Naeini  5
Affiliations

Characteristics of Primary Cutaneous T-Cell Lymphoma in Iran: A 10-Year Retrospective Study

Farahnaz Fatemi Naeini et al. Int Sch Res Notices. .

Abstract

Background. Primary cutaneous T-cell lymphomas (CTCLs) are a group of extranodal non-Hodgkin lymphomas that may be present in the skin without any evidence of extracutaneous disease. The aim of this study was to evaluate the epidemiological characteristics of primary CTCL in Isfahan, Iran. Method. A total of 95 patients who were diagnosed as having primary CTCL were recruited during a 10-year period (2003-2013) and were classified according to the new WHO-EORTC criteria. Results. The patient group consisted of 43 (44.8%) males and 53 (55.2%) females, which indicated a female predominance (M : F ratio 1 : 1.2). The mean age at the time of diagnosis was 41.78 ± 16.88 years (range: 7-84 years). Prior to diagnosis, the lesions had persisted for a mean of 8.34 ± 4.38 years (range: 0-55 years). The age at peak diagnosis was 20-40 years (43%). The most frequent subtypes were mycosis fungoides (MF) (88.5%). Four patients died from CTCL-related complications. Conclusions. The distinguishing epidemiologic characteristics of primary CTCL, particularly those MF, in Iran, are the absence of a male predominance and lower age at diagnosis. This is likely because of the characteristic ethnic group diversity and increased susceptibility among younger population.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The age distribution of patients with primary CTCL.
Figure 2
Figure 2
Mycosis fungoides. Erythematous plaques affected the trunk area.
Figure 3
Figure 3
Erythrodermic mycosis fungoides. Advanced stage of mycosis fungoides in a 25-year-old man.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Groves F. D., Linet M. S., Travis L. B., Devesa S. S. Cancer surveillance series: non-Hodgkin's lymphoma incidence by histologic subtype in the United States from 1978 through 1995. Journal of the National Cancer Institute. 2000;92(15):1240–1251. doi: 10.1093/jnci/92.15.1240. - DOI - PubMed
    1. Wilcox R. A. Cutaneous T-cell lymphoma: 2014 update on diagnosis, risk-stratification, and management. American Journal of Hematology. 2014;89:837–851. - PubMed
    1. Willemze R., Jaffe E. S., Burg G., et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768–3785. doi: 10.1182/blood-2004-09-3502. - DOI - PubMed
    1. Bradford P. T., Devesa S. S., Anderson W. F., Toro J. R. Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases. Blood. 2009;113(21):5064–5073. doi: 10.1182/blood-2008-10-184168. - DOI - PMC - PubMed
    1. Jenni D., Karpova M. B., Seifert B., et al. Primary cutaneous lymphoma: two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre. British Journal of Dermatology. 2011;164(5):1071–1077. doi: 10.1111/j.1365-2133.2010.10143.x. - DOI - PubMed

LinkOut - more resources