Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2016 Sep 13;7(37):59029-59048.
doi: 10.18632/oncotarget.10665.

A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis

Rafael Ríos-Tamayo  1   2 , Carmen Belén Lupiañez  1   2 , Daniele Campa  3 , Thomas Hielscher  4 , Niels Weinhold  5   6 , Joaquin Martínez-López  7 , Andrés Jerez  8 , Stefano Landi  3 , Krzysztof Jamroziak  9 , Charles Dumontet  10 , Marzena Wątek  11 , Fabienne Lesueur  12   13   14   15 , Rui Manuel Reis  16   17   18 , Herlander Marques  16   17 , Artur Jurczyszyn  19 , Ulla Vogel  20 , Gabriele Buda  21 , Ramón García-Sanz  22 , Enrico Orciuolo  21 , Mario Petrini  21 , Annette J Vangsted  23 , Federica Gemignani  3 , Asta Försti  24 , Hartmut Goldschmidt  6   25 , Kari Hemminki  24 , Federico Canzian  10 , Manuel Jurado  1   2 , Juan Sainz  1   2
Affiliations
Meta-Analysis

A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis

Rafael Ríos-Tamayo et al. Oncotarget. .

Abstract

Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.

Keywords: diabetes; genetic variants; multiple myeloma; survival.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

All authors have nothing to disclose.

Figures

Figure 1
Figure 1. Kaplan-Meier plots for the HNF1Brs7501939 SNP in the IMMENSE (A) and Heidelberg (B) populations
See this image and copyright information in PMC

References

    1. Alexander DD, Mink PJ, Adami HO, Cole P, Mandel JS, Oken MM, Trichopoulos D. Multiple myeloma: a review of the epidemiologic literature. Int J Cancer. 2007;120:40–61. - PubMed
    1. Rios-Tamayo R, Sanchez MJ, Puerta JM, Sainz J, Chang DY, Rodriguez T, Lopez P, de Pablos JM, Navarro P, de Veas JL, Romero A, Garrido P, Moratalla L, et al. Trends in survival of multiple myeloma: a thirty-year population-based study in a single institution. Cancer Epidemiol. 2015;39:693–699. - PubMed
    1. Kumar SK, Rajkumar SV, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Zeldenrust SR, Dingli D, Russell SJ, Lust JA, Greipp PR, Kyle RA, Gertz MA. Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008;111:2516–2520. - PMC - PubMed
    1. Avet-Loiseau H, Attal M, Campion L, Caillot D, Hulin C, Marit G, Stoppa AM, Voillat L, Wetterwald M, Pegourie B, Voog E, Tiab M, Banos A, et al. Long-term analysis of the IFM 99 trials for myeloma: cytogenetic abnormalities [t(4;14), del(17p), 1q gains] play a major role in defining long-term survival. J Clin Oncol. 2012;30:1949–1952. - PubMed
    1. Ludwig H, Bolejack V, Crowley J, Blade J, Miguel JS, Kyle RA, Rajkumar SV, Shimizu K, Turesson I, Westin J, Sonneveld P, Cavo M, Boccadoro M, et al. Survival and years of life lost in different age cohorts of patients with multiple myeloma. J Clin Oncol. 2010;28:1599–1605. - PubMed

Publication types