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Review
. 2016 May-Jun;91(3):336-43.
doi: 10.1590/abd1806-4841.20164180.

Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review

Cesar Daniel Villarreal Villarreal  1 , Julio Cesar Salas Alanis  2 , Jose Carlos Jaime Pérez  1 , Jorge Ocampo Candiani  1
Affiliations
Review

Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review

Cesar Daniel Villarreal Villarreal et al. An Bras Dermatol. 2016 May-Jun.

Abstract

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. We discuss various insights into the disease's mechanisms and the different treatments for acute and chronic skin graft-versus-host disease.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
Histological aspects of cutaneous GVHD. Skin biopsy of cutaneous GVHD: hyperkeratosis, hypergranulosis associated with lichenoid inflammatory infiltrate is observed. (10X, HyE)
Figure 2
Figure 2
Histological aspects of cutaneous GVHD. Skin biopsy of cutaneous GVHD: Epidermal Basal cell apoptosis associated with melanin pigment deposits are present near the basement membrane zone. (40X, HyE)
Figure 3
Figure 3
Clinical manifestations of cutaneous GVHD. Patient with GVHD grade 3, maculopapular erythematous rash affecting the an terior portion of thorax and extremities
Figure 4
Figure 4
Clinical manifestations of cutaneous GVHD. Patient with GVHD grade 3, maculopapular erythematous rash affecting the posterior portion of thorax
See this image and copyright information in PMC

References

    1. Kernan NA, Collins NH, Juliano L, Cartagena T, Dupont B, O'Reilly RJ. Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease. Blood. 1986;68:770–773. - PubMed
    1. Jagasia M, Arora M, Flowers ME, Chao NJ, McCarthy PL, Cutler CS, et al. Risk factors for acute GVHD and survival after hematopoietic cell transplantation. Blood. 2012;119:296–307. - PMC - PubMed
    1. Weisdorf D, Haake R, Blazar B, Miller W, McGlave P, Ramsay N, et al. Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantationan analysis of clinical risk features and outcome. Blood. 1990;75:1024–1030. - PubMed
    1. Farmer ER. Human cutaneous graft-versus-host disease. J Invest Dermatol. 1985;85:124s–128s. - PubMed
    1. Garnett C, Apperley JF, Pavlů J. Treatment and management of graft-versus-host diseaseimproving response and survival. Ther Adv Hematol. 2013;4:366–378. - PMC - PubMed

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