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Case Reports
. 2016 May-Jun;91(3):375-7.
doi: 10.1590/abd1806-4841.20163960.

Ulcerations due to methotrexate toxicity in a psoriasis patient

Claudia Fernanda Dias Souza  1 , Olga Milena Zarco Suarez  1 , Talita Fonseca Medeiros da Silva  1 , Ana Carolina Lourenço Araújo Gorenstein  1 , Leonardo Pereira Quintella  1   2 , João Carlos Regazzi Avelleira  1
Affiliations
Case Reports

Ulcerations due to methotrexate toxicity in a psoriasis patient

Claudia Fernanda Dias Souza et al. An Bras Dermatol. 2016 May-Jun.

Abstract

Methotrexate is one of the most used drugs in the treatment of psoriasis with indication of systemic therapy. Cutaneous and mucous side effects are described by pharmacological characteristics of the drug itself or due to overdose. We report the case of a patient with ulcerations in oral mucosa and psoriatic plaques after incorrect use of Methotrexate. Prescribed in a weekly dose, it was used continuously for 10 days and without simultaneous intake of folic acid. It is important to ensure correct comprehension of the prescription.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
Ulcerated lesion on oral mu cosa
Figure 2
Figure 2
Ulcerated areas in the a periphery of psoriatic plaques on upper limbs
Figure 3
Figure 3
In closer de tail, on left knee
Figure 4
Figure 4
Histopathology: Ulcerated area covered by exudate and regenerating epithelium. Proliferating vessels and neutrophils
See this image and copyright information in PMC

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