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Review
. 2016 Jul 18;6(3):21.
doi: 10.3390/brainsci6030021.

DBS for Obesity

Ruth Franco  1 , Erich T Fonoff  2 , Pedro Alvarenga  3 , Antonio Carlos Lopes  4 , Euripides C Miguel  5 , Manoel J Teixeira  6 , Durval Damiani  7 , Clement Hamani  8   9   10
Affiliations
Review

DBS for Obesity

Ruth Franco et al. Brain Sci. .

Abstract

Obesity is a chronic, progressive and prevalent disorder. Morbid obesity, in particular, is associated with numerous comorbidities and early mortality. In patients with morbid obesity, pharmacological and behavioral approaches often have limited results. Bariatric surgery is quite effective but is associated with operative failures and a non-negligible incidence of side effects. In the last decades, deep brain stimulation (DBS) has been investigated as a neurosurgical modality to treat various neuropsychiatric disorders. In this article we review the rationale for selecting different brain targets, surgical results and future perspectives for the use of DBS in medically refractory obesity.

Keywords: deep brain stimulation; hypothalamus; nucleus accumbens; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. World Health Organization (WHO) Obesity and Overweight. [(accessed on 11 July 2016)]. Available online: http://www.who.int/mediacentre/factsheets/fs311/en/
    1. Finucane M.M., Stevens G.A., Cowan M.J., Danaei G., Lin J.K., Paciorek C.J., Singh G.M., Gutierrez H.R., Lu Y., Bahalim A.N., et al. National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377:557–567. doi: 10.1016/S0140-6736(10)62037-5. - DOI - PMC - PubMed
    1. Fontaine K.R., Redden D.T., Wang C., Westfall A.O., Allison D.B. Years of life lost due to obesity. JAMA. 2003;289:187–193. doi: 10.1001/jama.289.2.187. - DOI - PubMed
    1. Flegal K.M., Carroll M.D., Ogden C.L., Curtin L.R. Prevalence and trends in obesity among US adults, 1999–2008. JAMA. 2010;303:235–241. doi: 10.1001/jama.2009.2014. - DOI - PubMed
    1. Must A., Spadano J., Coakley E.H., Field A.E., Colditz G., Dietz W.H. The disease burden associated with overweight and obesity. JAMA. 1999;282:1523–1529. doi: 10.1001/jama.282.16.1523. - DOI - PubMed

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