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. 2016 Jul 20:16:505.
doi: 10.1186/s12885-016-2504-x.

Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer

Young Ho Yun  1   2 , Young Ae Kim  3 , Jin Ah Sim  4 , Ae Sun Shin  5 , Yoon Jung Chang  3 , Jongmog Lee  6 , Moon Soo Kim  6 , Young Mog Shim  7 , Jae Lll Zo  7
Affiliations

Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer

Young Ho Yun et al. BMC Cancer. .

Abstract

Background: We aimed to evaluate the prognostic value of quality of life (QOL) for predicting survival among disease-free survivors of surgically-treated lung cancer after the completion of cancer treatment.

Methods: We administered the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), the Quality of Life Questionnaire Lung Cancer Module (QLQ-LC13), Hospital Anxiety and Depression Scale (HADS), and Posttraumatic Growth Inventory (PTGI) to 809 survivors who were surgically-treated for lung cancer at two hospitals from 2001 through 2006. We gathered mortality data by linkage to the National Statistical Office through December 2011. We used Cox proportional hazard models to compute adjusted hazard ratios (aHRs) and 95 % confidence intervals (CIs) to estimate the relationship between QOL and survival.

Results: Analyses of QOL items adjusted for age, sex, stage, body mass index, and physical activity showed that scores for poor physical functioning, dyspnea, anorexia, diarrhea, cough, personal strength, anxiety, and depression were associated with poor survival. With adjustment for the independent indicators of survival, final multiple proportional hazard regression analyses of QOL show that physical functioning (aHR, 2.39; 95 % CI, 1.13-5.07), dyspnea (aHR, 1.56; 95 % CI, 1.01-2.40), personal strength (aHR, 2.36; 95 % CI, 1.31-4.27), and anxiety (aHR, 2.13; 95 % CI, 1.38-3.30) retained their independent prognostic power of survival.

Conclusion: This study suggests that patient-reported QOL outcomes in disease-free survivors of surgically-treated lung cancer after the completion of active treatment has independent prognostic value for long-term survival.

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Figures

Fig. 1
Fig. 1
Survival graph by among Lung Cancer Patients. Abbreviations: CI, Confidence Interval; Reference was the non-problematic group. a The hazard ratio was multivariable-adjusted for age at diagnosis, sex, cancer stage, BMI after surgery, dyspnea, personal strength, and anxiety. The problematic group for physical functioning was defined as one with a health related quality of life (HRQOL) score of 33or less. b The hazard ratio was multivariable-adjusted for age at diagnosis, sex, cancer stage, BMI after surgery, physical functioning, personal strength, and anxiety. The problematic group for dyspnea was defined as one with a symptom scale score of 66 or higher. c The hazard ratio was multivariable-adjusted for age at diagnosis, sex, cancer stage, BMI after surgery, physical functioning, dyspnea, and anxiety. The problematic group for personal strength was defined as one with a PTGI factor of 15 or less. d The hazard ratio was multivariable-adjusted for age at diagnosis, sex, cancer stage, BMI after surgery, physical functioning, dyspnea, and personal strength. The problematic group for Anxiety was defined as one with a HADS of 8 or higher
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