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Case Reports
. 2016 Jun 28;8(2):6241.
doi: 10.4081/rt.2016.6241.

Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma

Maria S Sayapina  1 , Nikita A Savelov  2 , Apollon I Karseladze  1 , Anatoly A Bulanov  1 , Alexey A Tryakin  1 , Dmitry A Nosov  1 , Avgust M Garin  1 , Sergey A Tjulandin  1
Affiliations
Case Reports

Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma

Maria S Sayapina et al. Rare Tumors. .

Abstract

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies.

Keywords: Nuclear protein of the testis midline carcinoma; histone deacetylase inhibitors; primary mediastinal seminoma.

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Conflict of interest statement

Conflict of interest: the authors declare no potential conflict of interest.

Figures

Figure 1.
Figure 1.
Coronal computed tomography image of the chest and abdomen before treatment.
Figure 2.
Figure 2.
Diagnosis of nuclear protein of the testis (NUT) midline carcinoma. A) Undifferentiated small cells with foci of squamous differentiation (Hematoxylin & Eosin, 20×). B) Immunohistochemistry of tumor cell nuclei showing speckled staining for NUT (250×) using anti-NUT rabbit polyclonal antibody (clone C52, 1:100).
Figure 3.
Figure 3.
A) Coronal computed tomography (CT) image of the chest after treatment with histone deacetylase inhibitors, indicating marked adverse change from the time of diagnosis. There is encasement of major vessels, right atrium and right ventricle. B) Coronal CT image of the abdomen. There are metastases in liver that had significantly increased in size.
See this image and copyright information in PMC

References

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